Small prosthesis size in aortic valve replacement does not affect mortality

Damien J. Lapar, Gorav Ailawadi, Castigliano Bhamidipati, George Stukenborg, Ivan K. Crosby, John A. Kern, Irving L. Kron

Research output: Contribution to journalArticle

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Abstract

Background: Small prosthesis size has been associated with poorer postoperative outcomes in aortic valve replacement (AVR). We hypothesized that the use of small aortic valve (AV) prostheses does not independently increase operative mortality following AVR, but that mortality may instead be related to comorbidities. Methods: We examined the mortality among 4,621 patients who underwent primary AVR operations at 13 different statewide centers from 2003 to 2008. Patients were stratified by prosthesis size into groups with small (≤ 21 mm, n = 1,810) and standard AV prostheses (< 23 mm, n = 2,811). The effect of prosthesis size on outcomes was evaluated with univariate and multivariable regression analyses. Results: Operative mortality among patients undergoing primary AVR operations was 3.7%. Among isolated operations, small AV prostheses were implanted in more females (79.9% vs 21.0%, p < 0.001) and older patients (68.9 ± 12.3 years vs 63.8 ± 13.9 years, p < 0.001) than were standard-size AV prostheses, and carried a higher predicted risk of mortality according to the Society of Thoracic Surgeons Predicted Risk of Mortality Score (3.1 [interquartile range, 3.0] versus 2.2 [2.0], p < 0.001) than did standard-size AV prostheses. Small AV prostheses incurred more major complications (19.5% vs 15.7%, p = 0.01), a greater mortality (3.9% vs 2.3%, p = 0.03), a longer postoperative length of stay (6.0 [3.0] vs 5.0 [3.0] days, p < 0.001), and higher total costs ($29,738 [18,196] vs $26,679 [14,890], p < 0.001) than did standard AV prostheses. However, when analyzed with multivariate regression, small AV prosthesis size and female gender were not independent predictors of operative mortality, whereas advanced age, cardiopulmonary bypass time, and aortic annular enlargement were important predictors of operative mortality. Conclusions: Small aortic valve prosthesis size does not independently increase operative mortality following primary AVR. Increased morbidity and mortality among patients undergoing the implantation of small AV prostheses is related to the confounding effects of preoperative and operative risk factors. Annular enlargement may not always reduce mortality.

Original languageEnglish (US)
Pages (from-to)880-888
Number of pages9
JournalAnnals of Thoracic Surgery
Volume92
Issue number3
DOIs
StatePublished - Sep 1 2011
Externally publishedYes

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Aortic Valve
Prostheses and Implants
Mortality
Cardiopulmonary Bypass
Comorbidity
Length of Stay

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Lapar, D. J., Ailawadi, G., Bhamidipati, C., Stukenborg, G., Crosby, I. K., Kern, J. A., & Kron, I. L. (2011). Small prosthesis size in aortic valve replacement does not affect mortality. Annals of Thoracic Surgery, 92(3), 880-888. https://doi.org/10.1016/j.athoracsur.2011.04.105

Small prosthesis size in aortic valve replacement does not affect mortality. / Lapar, Damien J.; Ailawadi, Gorav; Bhamidipati, Castigliano; Stukenborg, George; Crosby, Ivan K.; Kern, John A.; Kron, Irving L.

In: Annals of Thoracic Surgery, Vol. 92, No. 3, 01.09.2011, p. 880-888.

Research output: Contribution to journalArticle

Lapar, DJ, Ailawadi, G, Bhamidipati, C, Stukenborg, G, Crosby, IK, Kern, JA & Kron, IL 2011, 'Small prosthesis size in aortic valve replacement does not affect mortality', Annals of Thoracic Surgery, vol. 92, no. 3, pp. 880-888. https://doi.org/10.1016/j.athoracsur.2011.04.105
Lapar, Damien J. ; Ailawadi, Gorav ; Bhamidipati, Castigliano ; Stukenborg, George ; Crosby, Ivan K. ; Kern, John A. ; Kron, Irving L. / Small prosthesis size in aortic valve replacement does not affect mortality. In: Annals of Thoracic Surgery. 2011 ; Vol. 92, No. 3. pp. 880-888.
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title = "Small prosthesis size in aortic valve replacement does not affect mortality",
abstract = "Background: Small prosthesis size has been associated with poorer postoperative outcomes in aortic valve replacement (AVR). We hypothesized that the use of small aortic valve (AV) prostheses does not independently increase operative mortality following AVR, but that mortality may instead be related to comorbidities. Methods: We examined the mortality among 4,621 patients who underwent primary AVR operations at 13 different statewide centers from 2003 to 2008. Patients were stratified by prosthesis size into groups with small (≤ 21 mm, n = 1,810) and standard AV prostheses (< 23 mm, n = 2,811). The effect of prosthesis size on outcomes was evaluated with univariate and multivariable regression analyses. Results: Operative mortality among patients undergoing primary AVR operations was 3.7{\%}. Among isolated operations, small AV prostheses were implanted in more females (79.9{\%} vs 21.0{\%}, p < 0.001) and older patients (68.9 ± 12.3 years vs 63.8 ± 13.9 years, p < 0.001) than were standard-size AV prostheses, and carried a higher predicted risk of mortality according to the Society of Thoracic Surgeons Predicted Risk of Mortality Score (3.1 [interquartile range, 3.0] versus 2.2 [2.0], p < 0.001) than did standard-size AV prostheses. Small AV prostheses incurred more major complications (19.5{\%} vs 15.7{\%}, p = 0.01), a greater mortality (3.9{\%} vs 2.3{\%}, p = 0.03), a longer postoperative length of stay (6.0 [3.0] vs 5.0 [3.0] days, p < 0.001), and higher total costs ($29,738 [18,196] vs $26,679 [14,890], p < 0.001) than did standard AV prostheses. However, when analyzed with multivariate regression, small AV prosthesis size and female gender were not independent predictors of operative mortality, whereas advanced age, cardiopulmonary bypass time, and aortic annular enlargement were important predictors of operative mortality. Conclusions: Small aortic valve prosthesis size does not independently increase operative mortality following primary AVR. Increased morbidity and mortality among patients undergoing the implantation of small AV prostheses is related to the confounding effects of preoperative and operative risk factors. Annular enlargement may not always reduce mortality.",
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AU - Lapar, Damien J.

AU - Ailawadi, Gorav

AU - Bhamidipati, Castigliano

AU - Stukenborg, George

AU - Crosby, Ivan K.

AU - Kern, John A.

AU - Kron, Irving L.

PY - 2011/9/1

Y1 - 2011/9/1

N2 - Background: Small prosthesis size has been associated with poorer postoperative outcomes in aortic valve replacement (AVR). We hypothesized that the use of small aortic valve (AV) prostheses does not independently increase operative mortality following AVR, but that mortality may instead be related to comorbidities. Methods: We examined the mortality among 4,621 patients who underwent primary AVR operations at 13 different statewide centers from 2003 to 2008. Patients were stratified by prosthesis size into groups with small (≤ 21 mm, n = 1,810) and standard AV prostheses (< 23 mm, n = 2,811). The effect of prosthesis size on outcomes was evaluated with univariate and multivariable regression analyses. Results: Operative mortality among patients undergoing primary AVR operations was 3.7%. Among isolated operations, small AV prostheses were implanted in more females (79.9% vs 21.0%, p < 0.001) and older patients (68.9 ± 12.3 years vs 63.8 ± 13.9 years, p < 0.001) than were standard-size AV prostheses, and carried a higher predicted risk of mortality according to the Society of Thoracic Surgeons Predicted Risk of Mortality Score (3.1 [interquartile range, 3.0] versus 2.2 [2.0], p < 0.001) than did standard-size AV prostheses. Small AV prostheses incurred more major complications (19.5% vs 15.7%, p = 0.01), a greater mortality (3.9% vs 2.3%, p = 0.03), a longer postoperative length of stay (6.0 [3.0] vs 5.0 [3.0] days, p < 0.001), and higher total costs ($29,738 [18,196] vs $26,679 [14,890], p < 0.001) than did standard AV prostheses. However, when analyzed with multivariate regression, small AV prosthesis size and female gender were not independent predictors of operative mortality, whereas advanced age, cardiopulmonary bypass time, and aortic annular enlargement were important predictors of operative mortality. Conclusions: Small aortic valve prosthesis size does not independently increase operative mortality following primary AVR. Increased morbidity and mortality among patients undergoing the implantation of small AV prostheses is related to the confounding effects of preoperative and operative risk factors. Annular enlargement may not always reduce mortality.

AB - Background: Small prosthesis size has been associated with poorer postoperative outcomes in aortic valve replacement (AVR). We hypothesized that the use of small aortic valve (AV) prostheses does not independently increase operative mortality following AVR, but that mortality may instead be related to comorbidities. Methods: We examined the mortality among 4,621 patients who underwent primary AVR operations at 13 different statewide centers from 2003 to 2008. Patients were stratified by prosthesis size into groups with small (≤ 21 mm, n = 1,810) and standard AV prostheses (< 23 mm, n = 2,811). The effect of prosthesis size on outcomes was evaluated with univariate and multivariable regression analyses. Results: Operative mortality among patients undergoing primary AVR operations was 3.7%. Among isolated operations, small AV prostheses were implanted in more females (79.9% vs 21.0%, p < 0.001) and older patients (68.9 ± 12.3 years vs 63.8 ± 13.9 years, p < 0.001) than were standard-size AV prostheses, and carried a higher predicted risk of mortality according to the Society of Thoracic Surgeons Predicted Risk of Mortality Score (3.1 [interquartile range, 3.0] versus 2.2 [2.0], p < 0.001) than did standard-size AV prostheses. Small AV prostheses incurred more major complications (19.5% vs 15.7%, p = 0.01), a greater mortality (3.9% vs 2.3%, p = 0.03), a longer postoperative length of stay (6.0 [3.0] vs 5.0 [3.0] days, p < 0.001), and higher total costs ($29,738 [18,196] vs $26,679 [14,890], p < 0.001) than did standard AV prostheses. However, when analyzed with multivariate regression, small AV prosthesis size and female gender were not independent predictors of operative mortality, whereas advanced age, cardiopulmonary bypass time, and aortic annular enlargement were important predictors of operative mortality. Conclusions: Small aortic valve prosthesis size does not independently increase operative mortality following primary AVR. Increased morbidity and mortality among patients undergoing the implantation of small AV prostheses is related to the confounding effects of preoperative and operative risk factors. Annular enlargement may not always reduce mortality.

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