Small intestine CD4+ T cells are profoundly depleted during acute simian-human immunodeficiency virus infection, regardless of viral pathogenicity

Yoshinori Fukazawa, Ariko Miyake, Kentaro Ibuki, Katsuhisa Inaba, Naoki Saito, Makiko Motohara, Reii Horiuchi, Ai Himeno, Kenta Matsuda, Megumi Matsuyama, Hidemi Takahashi, Masanori Hayami, Tatsuhiko Igarashi, Tomoyuki Miura

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

To analyze the relationship between acute virus-induced injury and the subsequent disease phenotype, we compared the virus replication and CD4 + T-cell profiles for monkeys infected with isogenic highly pathogenic (KS661) and moderately pathogenic (#64) simian-human immunodeficiency viruses (SHIVs). Intrarectal infusion of SHIV-KS661 resulted in rapid, systemic, and massive virus replication, while SHIV-#64 replicated more slowly and reached lower titers. Whereas KS661 systemically depleted CD4+ T cells, #64 caused significant CD4+ T-cell depletion only in the small intestine. We conclude that SHIV, regardless of pathogenicity, can cause injury to the small intestine and leads to CD4+ T-cell depletion in infected animals during acute infection.

Original languageEnglish (US)
Pages (from-to)6039-6044
Number of pages6
JournalJournal of Virology
Volume82
Issue number12
DOIs
StatePublished - Jun 2008
Externally publishedYes

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Simian Immunodeficiency Virus
Human immunodeficiency virus
HIV infections
Virus Diseases
Small Intestine
Virulence
small intestine
pathogenicity
T-lymphocytes
HIV
T-Lymphocytes
Virus Replication
virus replication
Wounds and Injuries
Haplorhini
monkeys
Viruses
Phenotype
phenotype
viruses

ASJC Scopus subject areas

  • Immunology

Cite this

Small intestine CD4+ T cells are profoundly depleted during acute simian-human immunodeficiency virus infection, regardless of viral pathogenicity. / Fukazawa, Yoshinori; Miyake, Ariko; Ibuki, Kentaro; Inaba, Katsuhisa; Saito, Naoki; Motohara, Makiko; Horiuchi, Reii; Himeno, Ai; Matsuda, Kenta; Matsuyama, Megumi; Takahashi, Hidemi; Hayami, Masanori; Igarashi, Tatsuhiko; Miura, Tomoyuki.

In: Journal of Virology, Vol. 82, No. 12, 06.2008, p. 6039-6044.

Research output: Contribution to journalArticle

Fukazawa, Y, Miyake, A, Ibuki, K, Inaba, K, Saito, N, Motohara, M, Horiuchi, R, Himeno, A, Matsuda, K, Matsuyama, M, Takahashi, H, Hayami, M, Igarashi, T & Miura, T 2008, 'Small intestine CD4+ T cells are profoundly depleted during acute simian-human immunodeficiency virus infection, regardless of viral pathogenicity', Journal of Virology, vol. 82, no. 12, pp. 6039-6044. https://doi.org/10.1128/JVI.02753-07
Fukazawa, Yoshinori ; Miyake, Ariko ; Ibuki, Kentaro ; Inaba, Katsuhisa ; Saito, Naoki ; Motohara, Makiko ; Horiuchi, Reii ; Himeno, Ai ; Matsuda, Kenta ; Matsuyama, Megumi ; Takahashi, Hidemi ; Hayami, Masanori ; Igarashi, Tatsuhiko ; Miura, Tomoyuki. / Small intestine CD4+ T cells are profoundly depleted during acute simian-human immunodeficiency virus infection, regardless of viral pathogenicity. In: Journal of Virology. 2008 ; Vol. 82, No. 12. pp. 6039-6044.
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AU - Saito, Naoki

AU - Motohara, Makiko

AU - Horiuchi, Reii

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AU - Matsuyama, Megumi

AU - Takahashi, Hidemi

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