Small intestine CD4+ cell reduction and enteropathy in simian/human immunodeficiency virus KS661-infected rhesus macaques in the presence of low viral load

Katsuhisa Inaba, Yoshinori Fukazawa, Kenta Matsuda, Ai Himeno, Megumi Matsuyama, Kentaro Ibuki, Yoshiharu Miura, Yoshio Koyanagi, Atsushi Nakajima, Richard S. Blumberg, Hidemi Takahashi, Masanori Hayami, Tatsuhiko Igarashi, Tomoyuki Miura

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Human immunodeficiency virus type 1, simian immunodeficiency virus and simian/human immunodeficiency virus (SHIV) infection generally lead to death of the host accompanied by high viraemia and profound CD4+ T-cell depletion. SHIV clone KS661-infected rhesus macaques with a high viral load set point (HVL) ultimately experience diarrhoea and wasting at 6-12 months after infection. In contrast, infected macaques with a low viral load set point (LVL) usually live asymptomatically throughout the observation period, and are therefore referred to as asymptomatic LVL (Asym LVL) macaques. Interestingly, some LVL macaques exhibit diarrhoea and wasting similar to the symptoms of HVL macaques and are termed symptomatic LVL (Sym LVL) macaques. This study tested the hypothesis that Sym LVL macaques have the same degree of intestinal abnormalities as HVL macaques. The proviral DNA loads in lymphoid tissue and the intestines of Sym LVL and Asym LVL macaques were comparable and all infected monkeys showed villous atrophy. Notably, the CD4+ cell frequencies of lymphoid tissues and intestines in Sym LVL macaques were remarkably lower than those in Asym LVL and uninfected macaques. Furthermore, Sym LVL and HVL macaques exhibited an increased number of activated macrophages. In conclusion, intestinal disorders including CD4+ cell reduction and abnormal immune activation can be observed in SHIV-KS661-infected macaques independent of virus replication levels.

Original languageEnglish (US)
Pages (from-to)773-781
Number of pages9
JournalJournal of General Virology
Volume91
Issue number3
DOIs
StatePublished - 2010
Externally publishedYes

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Simian Immunodeficiency Virus
Macaca
Macaca mulatta
Viral Load
Small Intestine
HIV
Lymphoid Tissue
Intestines
Diarrhea
Viremia
Virus Diseases
Virus Replication
Atrophy
Haplorhini
HIV-1
Clone Cells

ASJC Scopus subject areas

  • Virology

Cite this

Small intestine CD4+ cell reduction and enteropathy in simian/human immunodeficiency virus KS661-infected rhesus macaques in the presence of low viral load. / Inaba, Katsuhisa; Fukazawa, Yoshinori; Matsuda, Kenta; Himeno, Ai; Matsuyama, Megumi; Ibuki, Kentaro; Miura, Yoshiharu; Koyanagi, Yoshio; Nakajima, Atsushi; Blumberg, Richard S.; Takahashi, Hidemi; Hayami, Masanori; Igarashi, Tatsuhiko; Miura, Tomoyuki.

In: Journal of General Virology, Vol. 91, No. 3, 2010, p. 773-781.

Research output: Contribution to journalArticle

Inaba, K, Fukazawa, Y, Matsuda, K, Himeno, A, Matsuyama, M, Ibuki, K, Miura, Y, Koyanagi, Y, Nakajima, A, Blumberg, RS, Takahashi, H, Hayami, M, Igarashi, T & Miura, T 2010, 'Small intestine CD4+ cell reduction and enteropathy in simian/human immunodeficiency virus KS661-infected rhesus macaques in the presence of low viral load', Journal of General Virology, vol. 91, no. 3, pp. 773-781. https://doi.org/10.1099/vir.0.017368-0
Inaba, Katsuhisa ; Fukazawa, Yoshinori ; Matsuda, Kenta ; Himeno, Ai ; Matsuyama, Megumi ; Ibuki, Kentaro ; Miura, Yoshiharu ; Koyanagi, Yoshio ; Nakajima, Atsushi ; Blumberg, Richard S. ; Takahashi, Hidemi ; Hayami, Masanori ; Igarashi, Tatsuhiko ; Miura, Tomoyuki. / Small intestine CD4+ cell reduction and enteropathy in simian/human immunodeficiency virus KS661-infected rhesus macaques in the presence of low viral load. In: Journal of General Virology. 2010 ; Vol. 91, No. 3. pp. 773-781.
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AU - Matsuda, Kenta

AU - Himeno, Ai

AU - Matsuyama, Megumi

AU - Ibuki, Kentaro

AU - Miura, Yoshiharu

AU - Koyanagi, Yoshio

AU - Nakajima, Atsushi

AU - Blumberg, Richard S.

AU - Takahashi, Hidemi

AU - Hayami, Masanori

AU - Igarashi, Tatsuhiko

AU - Miura, Tomoyuki

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