Small intestinal submucosa plug for closure of dilated nephrostomy tracts: A pilot study in swine

Hideyaki Kakizawa, M. J. Conlin, Dusan Pavcnik, Barry Uchida, Marc Loriaux, Young Hwan Kim, Frederick S. Keller, Josef Rosch

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The aim of this study was to evaluate efficacy of a plug made of small intestinal submucosa (SIS) for closure of dilated nephrostomy tract in the kidney after nephroscopy. Ten kidneys in 5 swine had nephrostomy tracts dilated up to 8 mm. The SIS plug was placed into the dilated renal cortex under nephroscopic control. Follow-up arteriograms, retrograde pyelograms, and macroscopic and histologic studies at 24 h (n = 4), 6 weeks (n = 2), and 3 months (n = 4) were performed to evaluate the efficacy of the plug. The SIS plug effectively closed the dilated nephrostomy tract. Follow-up studies showed minimal changes of the kidneys, except for 1 small infarction, regarding inflammatory and foreign-body reactions and progressive scarring of the SIS. SIS plug is effective for occlusion of dilated nephrostomy tract after nephroscopy. Its efficacy should be compared with other therapeutic options.

Original languageEnglish (US)
Pages (from-to)596-600
Number of pages5
JournalCardiovascular and interventional radiology
Issue number3
StatePublished - Jun 2010


  • Biomaterial
  • Embolization
  • Interventional procedures
  • Kidneys
  • Small intestinal submucosa

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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