Small-conductance, calcium-activated potassium channels from mammalian brain

M. Köhler; B. Hirschberg; Chris Bond; J. M. Kinzie; N. V. Marrion; J. Maylie; John Adelman

doi:10.1126/science.273.5282.1709

Small-conductance, calcium-activated potassium channels from mammalian brain

M. Köhler, B. Hirschberg, Chris Bond, J. M. Kinzie, N. V. Marrion, J. Maylie, John Adelman

Obstetrics and Gynecology

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Abstract

Members of a previously unidentified family of potassium channel subunits were cloned from rat and human brain. The messenger RNAs encoding these subunits were widely expressed in brain with distinct yet overlapping patterns, as well as in several peripheral tissues. Expression of the messenger RNAs in Xenopus oocytes resulted in calcium-activated, voltage- independent potassium channels. The channels that formed from the various subunits displayed differential sensitivity to apamin and tubocurare. The distribution, function, and pharmacology of these channels are consistent with the SK class of small-conductance, calcium-activated potassium channels, which contribute to the afterhyperpolarization in central neurons and other cell types.

Original language	English (US)
Pages (from-to)	1709-1714
Number of pages	6
Journal	Science
Volume	273
Issue number	5282
DOIs	https://doi.org/10.1126/science.273.5282.1709
State	Published - Sep 20 1996

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abstract = "Members of a previously unidentified family of potassium channel subunits were cloned from rat and human brain. The messenger RNAs encoding these subunits were widely expressed in brain with distinct yet overlapping patterns, as well as in several peripheral tissues. Expression of the messenger RNAs in Xenopus oocytes resulted in calcium-activated, voltage- independent potassium channels. The channels that formed from the various subunits displayed differential sensitivity to apamin and tubocurare. The distribution, function, and pharmacology of these channels are consistent with the SK class of small-conductance, calcium-activated potassium channels, which contribute to the afterhyperpolarization in central neurons and other cell types.",

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AU - Bond, Chris

AU - Kinzie, J. M.

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AU - Maylie, J.

AU - Adelman, John

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Small-conductance, calcium-activated potassium channels from mammalian brain

Abstract

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