Small-conductance, calcium-activated potassium channels from mammalian brain

M. Köhler, B. Hirschberg, C. T. Bond, J. M. Kinzie, N. V. Marrion, J. Maylie, J. P. Adelman

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748 Scopus citations

Abstract

Members of a previously unidentified family of potassium channel subunits were cloned from rat and human brain. The messenger RNAs encoding these subunits were widely expressed in brain with distinct yet overlapping patterns, as well as in several peripheral tissues. Expression of the messenger RNAs in Xenopus oocytes resulted in calcium-activated, voltage- independent potassium channels. The channels that formed from the various subunits displayed differential sensitivity to apamin and tubocurare. The distribution, function, and pharmacology of these channels are consistent with the SK class of small-conductance, calcium-activated potassium channels, which contribute to the afterhyperpolarization in central neurons and other cell types.

Original languageEnglish (US)
Pages (from-to)1709-1714
Number of pages6
JournalScience
Volume273
Issue number5282
DOIs
StatePublished - Sep 20 1996

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    Köhler, M., Hirschberg, B., Bond, C. T., Kinzie, J. M., Marrion, N. V., Maylie, J., & Adelman, J. P. (1996). Small-conductance, calcium-activated potassium channels from mammalian brain. Science, 273(5282), 1709-1714. https://doi.org/10.1126/science.273.5282.1709