Small-conductance, calcium-activated potassium channels from mammalian brain

M. Köhler, B. Hirschberg, C. T. Bond, John (Mark) Kinzie, N. V. Marrion, James Maylie, John Adelman

Research output: Contribution to journalArticle

738 Citations (Scopus)

Abstract

Members of a previously unidentified family of potassium channel subunits were cloned from rat and human brain. The messenger RNAs encoding these subunits were widely expressed in brain with distinct yet overlapping patterns, as well as in several peripheral tissues. Expression of the messenger RNAs in Xenopus oocytes resulted in calcium-activated, voltage- independent potassium channels. The channels that formed from the various subunits displayed differential sensitivity to apamin and tubocurare. The distribution, function, and pharmacology of these channels are consistent with the SK class of small-conductance, calcium-activated potassium channels, which contribute to the afterhyperpolarization in central neurons and other cell types.

Original languageEnglish (US)
Pages (from-to)1709-1714
Number of pages6
JournalScience
Volume273
Issue number5282
StatePublished - Sep 20 1996
Externally publishedYes

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Small-Conductance Calcium-Activated Potassium Channels
Potassium Channels
Apamin
Tubocurarine
Messenger RNA
Brain
Xenopus
Oocytes
Pharmacology
Calcium
Neurons

ASJC Scopus subject areas

  • General

Cite this

Köhler, M., Hirschberg, B., Bond, C. T., Kinzie, J. M., Marrion, N. V., Maylie, J., & Adelman, J. (1996). Small-conductance, calcium-activated potassium channels from mammalian brain. Science, 273(5282), 1709-1714.

Small-conductance, calcium-activated potassium channels from mammalian brain. / Köhler, M.; Hirschberg, B.; Bond, C. T.; Kinzie, John (Mark); Marrion, N. V.; Maylie, James; Adelman, John.

In: Science, Vol. 273, No. 5282, 20.09.1996, p. 1709-1714.

Research output: Contribution to journalArticle

Köhler, M, Hirschberg, B, Bond, CT, Kinzie, JM, Marrion, NV, Maylie, J & Adelman, J 1996, 'Small-conductance, calcium-activated potassium channels from mammalian brain', Science, vol. 273, no. 5282, pp. 1709-1714.
Köhler M, Hirschberg B, Bond CT, Kinzie JM, Marrion NV, Maylie J et al. Small-conductance, calcium-activated potassium channels from mammalian brain. Science. 1996 Sep 20;273(5282):1709-1714.
Köhler, M. ; Hirschberg, B. ; Bond, C. T. ; Kinzie, John (Mark) ; Marrion, N. V. ; Maylie, James ; Adelman, John. / Small-conductance, calcium-activated potassium channels from mammalian brain. In: Science. 1996 ; Vol. 273, No. 5282. pp. 1709-1714.
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