Small conductance Ca2+-activated K+ channels modulate synaptic plasticity and memory encoding

Robert W. Stackman, Rebecca S. Hammond, Eftihia Linardatos, Aaron Gerlach, James Maylie, John Adelman, Thanos Tzounopoulos

Research output: Contribution to journalArticle

204 Citations (Scopus)

Abstract

Activity-dependent changes in neuronal excitability and synaptic strength are thought to underlie memory encoding. In hippocampal CA1 neurons, small conductance Ca2+-activated K+ (SK) channels contribute to the afterhyperpolarization, affecting neuronal excitability. In the present study, we examined the effect of apamin-sensitive SK channels on the induction of hippocampal synaptic plasticity in response to a range of stimulation frequencies. In addition, the role of apamin-sensitive SK channels on hippocampal-dependent memory encoding and retention was also tested. The results show that blocking SK channels with apamin increased the excitability of hippocampal neurons and facilitated the induction of synaptic plasticity by shifting the modification threshold to lower frequencies. This facilitation was NMDA receptor (NMDAR) dependent and appeared to be postsynaptic. Mice treated with apamin demonstrated accelerated hippocampal-dependent spatial and nonspatial memory encoding. They required fewer trials to learn the location of a hidden platform in the Morris water maze and less time to encode object memory in an object-recognition task compared with saline-treated mice. Apamin did not influence long-term retention of spatial or nonspatial memory. These data support a role for SK channels in the modulation of hippocampal synaptic plasticity and hippocampal-dependent memory encoding.

Original languageEnglish (US)
Pages (from-to)10163-10171
Number of pages9
JournalJournal of Neuroscience
Volume22
Issue number23
StatePublished - Dec 1 2002

Fingerprint

Apamin
Calcium-Activated Potassium Channels
Neuronal Plasticity
Neurons
N-Methyl-D-Aspartate Receptors
Water

Keywords

  • Ca-activated K channels
  • Excitability
  • Hippocampus
  • Object memory
  • Spatial memory
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Stackman, R. W., Hammond, R. S., Linardatos, E., Gerlach, A., Maylie, J., Adelman, J., & Tzounopoulos, T. (2002). Small conductance Ca2+-activated K+ channels modulate synaptic plasticity and memory encoding. Journal of Neuroscience, 22(23), 10163-10171.

Small conductance Ca2+-activated K+ channels modulate synaptic plasticity and memory encoding. / Stackman, Robert W.; Hammond, Rebecca S.; Linardatos, Eftihia; Gerlach, Aaron; Maylie, James; Adelman, John; Tzounopoulos, Thanos.

In: Journal of Neuroscience, Vol. 22, No. 23, 01.12.2002, p. 10163-10171.

Research output: Contribution to journalArticle

Stackman, RW, Hammond, RS, Linardatos, E, Gerlach, A, Maylie, J, Adelman, J & Tzounopoulos, T 2002, 'Small conductance Ca2+-activated K+ channels modulate synaptic plasticity and memory encoding', Journal of Neuroscience, vol. 22, no. 23, pp. 10163-10171.
Stackman RW, Hammond RS, Linardatos E, Gerlach A, Maylie J, Adelman J et al. Small conductance Ca2+-activated K+ channels modulate synaptic plasticity and memory encoding. Journal of Neuroscience. 2002 Dec 1;22(23):10163-10171.
Stackman, Robert W. ; Hammond, Rebecca S. ; Linardatos, Eftihia ; Gerlach, Aaron ; Maylie, James ; Adelman, John ; Tzounopoulos, Thanos. / Small conductance Ca2+-activated K+ channels modulate synaptic plasticity and memory encoding. In: Journal of Neuroscience. 2002 ; Vol. 22, No. 23. pp. 10163-10171.
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