Small-conductance Ca 2+-activated K + channels: Form and function

John P. Adelman, James Maylie, Pankaj Sah

Research output: Contribution to journalArticle

254 Scopus citations

Abstract

Small-conductance Ca 2+-activated K + channels (SK channels) are widely expressed throughout the central nervous system. These channels are activated solely by increases in intracellular Ca 2+. SK channels are stable macromolecular complexes of the ion poreforming subunits with calmodulin, which serves as the intrinsic Ca 2+ gating subunit, as well as with protein kinase CK2 and protein phosphatase 2A, which modulate Ca 2+ sensitivity. Well-known for their roles in regulating somatic excitability in central neurons, SK channels are also expressed in the postsynaptic membrane of glutamatergic synapses, where their activation and regulated trafficking modulate synaptic transmission and the induction and expression of synaptic plasticity, thereby affecting learning and memory. In this review we discuss the molecular and functional properties of SK channels and their physiological roles in central neurons.

Original languageEnglish (US)
Pages (from-to)245-269
Number of pages25
JournalAnnual Review of Physiology
Volume74
DOIs
StatePublished - Feb 27 2012

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Keywords

  • Ca gating
  • Intrinsic excitability
  • Learning and memory
  • Synaptic plasticity
  • Synaptic transmission

ASJC Scopus subject areas

  • Physiology

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