Sleep quality and disease severity in patients with chronic rhinosinusitis

Jeremiah A. Alt, Timothy Smith, Jess C. Mace, Zachary M. Soler

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Objectives/Hypothesis To evaluate sleep quality in patients with chronic rhinosinusitis (CRS) using a validated outcome measure and to compare measures of CRS disease severity with sleep dysfunction. Study Design Cross-sectional evaluation of a multi-center cohort. Methods According to the 2007 Adult Sinusitis Guidelines, patients with CRS were prospectively enrolled from four academic, tertiary care centers across North America. Each subject completed the Pittsburgh Sleep Quality Index (PSQI) instrument, in addition to CRS-specific measures of quality-of-life (QOL), endoscopy, computed tomography (CT), and olfaction. Patient demographics, comorbid conditions, and clinical measures of disease severity were compared between patients with "good" (PSQI; ≤5) and "poor" (PSQI; > 5) sleep quality. Results Patients (n = 268) reported a mean PSQI score of 9.4 (range: 0-21). Seventy-five percent of patients reported PSQI scores above the traditional cutoff, indicating poor sleep quality. Patients with poor sleep quality were found to have significantly worse QOL scores on both the Rhinosinusitis Disability Index (P <0.001) and 22-item Sinonasal Outcome Test (P <0.001). No significant differences in average endoscopy, CT, or olfactory function scores were found between patients with good or poor sleep quality. Tobacco smokers reported worse average PSQI total scores compared to nonsmokers (P = 0.030). Patients reporting poor sleep were more likely to have a history of depression, even after controlling for gender (P = 0.020). Conclusion The majority of patients with CRS have a poor quality of sleep, as measured by the PSQI survey. Poor sleep quality is significantly associated with CRS-specific QOL, gender, comorbid depression, and tobacco use, but not CT score or endoscopy grade. Level of Evidence 2b. Laryngoscope, 123:2364-2370, 2013

Original languageEnglish (US)
Pages (from-to)2364-2370
Number of pages7
JournalLaryngoscope
Volume123
Issue number10
DOIs
StatePublished - Oct 2013

Fingerprint

Sleep
Endoscopy
Tomography
Quality of Life
Depression
Laryngoscopes
Smell
Sinusitis
Tobacco Use
North America
Tertiary Care Centers
Tobacco
Chronic Disease
Cross-Sectional Studies
Demography
Outcome Assessment (Health Care)
Guidelines

Keywords

  • chronic disease
  • quality of life
  • rhinology
  • Sinusitis
  • sleep

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Sleep quality and disease severity in patients with chronic rhinosinusitis. / Alt, Jeremiah A.; Smith, Timothy; Mace, Jess C.; Soler, Zachary M.

In: Laryngoscope, Vol. 123, No. 10, 10.2013, p. 2364-2370.

Research output: Contribution to journalArticle

Alt, Jeremiah A. ; Smith, Timothy ; Mace, Jess C. ; Soler, Zachary M. / Sleep quality and disease severity in patients with chronic rhinosinusitis. In: Laryngoscope. 2013 ; Vol. 123, No. 10. pp. 2364-2370.
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N2 - Objectives/Hypothesis To evaluate sleep quality in patients with chronic rhinosinusitis (CRS) using a validated outcome measure and to compare measures of CRS disease severity with sleep dysfunction. Study Design Cross-sectional evaluation of a multi-center cohort. Methods According to the 2007 Adult Sinusitis Guidelines, patients with CRS were prospectively enrolled from four academic, tertiary care centers across North America. Each subject completed the Pittsburgh Sleep Quality Index (PSQI) instrument, in addition to CRS-specific measures of quality-of-life (QOL), endoscopy, computed tomography (CT), and olfaction. Patient demographics, comorbid conditions, and clinical measures of disease severity were compared between patients with "good" (PSQI; ≤5) and "poor" (PSQI; > 5) sleep quality. Results Patients (n = 268) reported a mean PSQI score of 9.4 (range: 0-21). Seventy-five percent of patients reported PSQI scores above the traditional cutoff, indicating poor sleep quality. Patients with poor sleep quality were found to have significantly worse QOL scores on both the Rhinosinusitis Disability Index (P <0.001) and 22-item Sinonasal Outcome Test (P <0.001). No significant differences in average endoscopy, CT, or olfactory function scores were found between patients with good or poor sleep quality. Tobacco smokers reported worse average PSQI total scores compared to nonsmokers (P = 0.030). Patients reporting poor sleep were more likely to have a history of depression, even after controlling for gender (P = 0.020). Conclusion The majority of patients with CRS have a poor quality of sleep, as measured by the PSQI survey. Poor sleep quality is significantly associated with CRS-specific QOL, gender, comorbid depression, and tobacco use, but not CT score or endoscopy grade. Level of Evidence 2b. Laryngoscope, 123:2364-2370, 2013

AB - Objectives/Hypothesis To evaluate sleep quality in patients with chronic rhinosinusitis (CRS) using a validated outcome measure and to compare measures of CRS disease severity with sleep dysfunction. Study Design Cross-sectional evaluation of a multi-center cohort. Methods According to the 2007 Adult Sinusitis Guidelines, patients with CRS were prospectively enrolled from four academic, tertiary care centers across North America. Each subject completed the Pittsburgh Sleep Quality Index (PSQI) instrument, in addition to CRS-specific measures of quality-of-life (QOL), endoscopy, computed tomography (CT), and olfaction. Patient demographics, comorbid conditions, and clinical measures of disease severity were compared between patients with "good" (PSQI; ≤5) and "poor" (PSQI; > 5) sleep quality. Results Patients (n = 268) reported a mean PSQI score of 9.4 (range: 0-21). Seventy-five percent of patients reported PSQI scores above the traditional cutoff, indicating poor sleep quality. Patients with poor sleep quality were found to have significantly worse QOL scores on both the Rhinosinusitis Disability Index (P <0.001) and 22-item Sinonasal Outcome Test (P <0.001). No significant differences in average endoscopy, CT, or olfactory function scores were found between patients with good or poor sleep quality. Tobacco smokers reported worse average PSQI total scores compared to nonsmokers (P = 0.030). Patients reporting poor sleep were more likely to have a history of depression, even after controlling for gender (P = 0.020). Conclusion The majority of patients with CRS have a poor quality of sleep, as measured by the PSQI survey. Poor sleep quality is significantly associated with CRS-specific QOL, gender, comorbid depression, and tobacco use, but not CT score or endoscopy grade. Level of Evidence 2b. Laryngoscope, 123:2364-2370, 2013

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