Sleep propensity free-runs with the temperature, melatonin and cortisol rhythms in a totally blind person

H. Nakagawa, R. L. Sack, A. J. Lewy

Research output: Contribution to journalArticle

100 Scopus citations


In previous studies, we found that many totally blind people have free- running melatonin rhythms but that free-running melatonin rhythms were not necessarily associated with periodic insomnia and daytime sleepiness. Thus, it was not clear if the circadian sleep propensity rhythm was free-running with the other circadian rhythms. In the present study, we report that the sleep propensity rhythm (as defined by an ultrashort sleep-wake schedule) free-ran with the melatonin, temperature and cortisol rhythms in a 44-year- old totally blind man even though he maintained a conventional sleep schedule and did not complain of clinically significant insomnia or excessive daytime sleepiness.

Original languageEnglish (US)
Pages (from-to)330-336
Number of pages7
Issue number4
StatePublished - Jan 1 1992



  • Blindness
  • Circadian rhythms
  • Cortisol
  • Melatonin
  • Sleep disorders
  • Temperature

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)

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