Sleep pathology in Creutzfeldt-Jakob disease

Peter Kang, Gabriela S. De Bruin, Leo H. Wang, Beth A. Ward, Beau M. Ances, Miranda Lim, Robert C. Bucelli

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Study Objectives: Associations between sleep and neurodegenerative diseases have become increasingly evident. This study aims to characterize the prevalence and type of sleep pathology in Creutzfeldt-Jakob disease (CJD), a rapidly progressive, fatal neurodegenerative disease. Methods: In this observational cross-sectional cohort study, we performed a retrospective analysis of sleep signs and symptoms in a consecutive group of patients with definite CJD at a tertiary care medical center (n = 28). Polysomnography was performed in 14 patients. Results: Although only 5 of 28 patients carried a premorbid sleep diagnosis, signs/symptoms of sleep pathology were present in 25 patients. Eleven reported hypersomnia whereas 13 reported insomnia. Seven had restless legs symptoms and/or periodic limb movements of sleep, and nine reported parasomnias. Of the 14 patients who underwent polysomnography, 1 did not show sleep, 9 (69%) had poorly formed or absent sleep spindles and/or K-complexes, and 10 (77%) had sleep-disordered breathing. Of the 8 patients who experienced rapid eye movement (REM) sleep during the polysomnography, 3 (38%) showed REM sleep without atonia, and 2 patients met criteria for REM sleep behavior disorder. Median total sleep time was 226 (interquartile range [IQR] = 195-282) min. Median sleep efficiency was 58.5% (IQR = 41-65.5 %). Median REM time was 0.35% (IQR = 0-7.125%). Five patients (38%) demonstrated periodic limb movements during polysomnography. One case is presented. Conclusions: Sleep pathology is common in CJD, and screening for sleep pathology is indicated in the evaluation of patients with rapidly progressive dementias. Early identification and treatment of sleep pathology may provide an intervenable target for CJD.

Original languageEnglish (US)
Pages (from-to)1033-1039
Number of pages7
JournalJournal of Clinical Sleep Medicine
Volume12
Issue number7
DOIs
StatePublished - Jan 1 2016

Fingerprint

Creutzfeldt-Jakob Syndrome
Sleep
Pathology
Polysomnography
REM Sleep
Neurodegenerative Diseases
Signs and Symptoms
Extremities
Parasomnias
REM Sleep Behavior Disorder
Disorders of Excessive Somnolence
Restless Legs Syndrome
Sleep Apnea Syndromes
Sleep Initiation and Maintenance Disorders
Tertiary Care Centers

Keywords

  • Creutzfeldt-Jakob disease
  • Dementia
  • Neurodegeneration
  • Prion diseases
  • Sleep disorders

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology

Cite this

Kang, P., De Bruin, G. S., Wang, L. H., Ward, B. A., Ances, B. M., Lim, M., & Bucelli, R. C. (2016). Sleep pathology in Creutzfeldt-Jakob disease. Journal of Clinical Sleep Medicine, 12(7), 1033-1039. https://doi.org/10.5664/jcsm.5944

Sleep pathology in Creutzfeldt-Jakob disease. / Kang, Peter; De Bruin, Gabriela S.; Wang, Leo H.; Ward, Beth A.; Ances, Beau M.; Lim, Miranda; Bucelli, Robert C.

In: Journal of Clinical Sleep Medicine, Vol. 12, No. 7, 01.01.2016, p. 1033-1039.

Research output: Contribution to journalArticle

Kang, P, De Bruin, GS, Wang, LH, Ward, BA, Ances, BM, Lim, M & Bucelli, RC 2016, 'Sleep pathology in Creutzfeldt-Jakob disease', Journal of Clinical Sleep Medicine, vol. 12, no. 7, pp. 1033-1039. https://doi.org/10.5664/jcsm.5944
Kang P, De Bruin GS, Wang LH, Ward BA, Ances BM, Lim M et al. Sleep pathology in Creutzfeldt-Jakob disease. Journal of Clinical Sleep Medicine. 2016 Jan 1;12(7):1033-1039. https://doi.org/10.5664/jcsm.5944
Kang, Peter ; De Bruin, Gabriela S. ; Wang, Leo H. ; Ward, Beth A. ; Ances, Beau M. ; Lim, Miranda ; Bucelli, Robert C. / Sleep pathology in Creutzfeldt-Jakob disease. In: Journal of Clinical Sleep Medicine. 2016 ; Vol. 12, No. 7. pp. 1033-1039.
@article{924f7bb4c1d94ca2ac6a0843b833c2be,
title = "Sleep pathology in Creutzfeldt-Jakob disease",
abstract = "Study Objectives: Associations between sleep and neurodegenerative diseases have become increasingly evident. This study aims to characterize the prevalence and type of sleep pathology in Creutzfeldt-Jakob disease (CJD), a rapidly progressive, fatal neurodegenerative disease. Methods: In this observational cross-sectional cohort study, we performed a retrospective analysis of sleep signs and symptoms in a consecutive group of patients with definite CJD at a tertiary care medical center (n = 28). Polysomnography was performed in 14 patients. Results: Although only 5 of 28 patients carried a premorbid sleep diagnosis, signs/symptoms of sleep pathology were present in 25 patients. Eleven reported hypersomnia whereas 13 reported insomnia. Seven had restless legs symptoms and/or periodic limb movements of sleep, and nine reported parasomnias. Of the 14 patients who underwent polysomnography, 1 did not show sleep, 9 (69{\%}) had poorly formed or absent sleep spindles and/or K-complexes, and 10 (77{\%}) had sleep-disordered breathing. Of the 8 patients who experienced rapid eye movement (REM) sleep during the polysomnography, 3 (38{\%}) showed REM sleep without atonia, and 2 patients met criteria for REM sleep behavior disorder. Median total sleep time was 226 (interquartile range [IQR] = 195-282) min. Median sleep efficiency was 58.5{\%} (IQR = 41-65.5 {\%}). Median REM time was 0.35{\%} (IQR = 0-7.125{\%}). Five patients (38{\%}) demonstrated periodic limb movements during polysomnography. One case is presented. Conclusions: Sleep pathology is common in CJD, and screening for sleep pathology is indicated in the evaluation of patients with rapidly progressive dementias. Early identification and treatment of sleep pathology may provide an intervenable target for CJD.",
keywords = "Creutzfeldt-Jakob disease, Dementia, Neurodegeneration, Prion diseases, Sleep disorders",
author = "Peter Kang and {De Bruin}, {Gabriela S.} and Wang, {Leo H.} and Ward, {Beth A.} and Ances, {Beau M.} and Miranda Lim and Bucelli, {Robert C.}",
year = "2016",
month = "1",
day = "1",
doi = "10.5664/jcsm.5944",
language = "English (US)",
volume = "12",
pages = "1033--1039",
journal = "Journal of Clinical Sleep Medicine",
issn = "1550-9389",
publisher = "American Academy of Sleep Medicine",
number = "7",

}

TY - JOUR

T1 - Sleep pathology in Creutzfeldt-Jakob disease

AU - Kang, Peter

AU - De Bruin, Gabriela S.

AU - Wang, Leo H.

AU - Ward, Beth A.

AU - Ances, Beau M.

AU - Lim, Miranda

AU - Bucelli, Robert C.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Study Objectives: Associations between sleep and neurodegenerative diseases have become increasingly evident. This study aims to characterize the prevalence and type of sleep pathology in Creutzfeldt-Jakob disease (CJD), a rapidly progressive, fatal neurodegenerative disease. Methods: In this observational cross-sectional cohort study, we performed a retrospective analysis of sleep signs and symptoms in a consecutive group of patients with definite CJD at a tertiary care medical center (n = 28). Polysomnography was performed in 14 patients. Results: Although only 5 of 28 patients carried a premorbid sleep diagnosis, signs/symptoms of sleep pathology were present in 25 patients. Eleven reported hypersomnia whereas 13 reported insomnia. Seven had restless legs symptoms and/or periodic limb movements of sleep, and nine reported parasomnias. Of the 14 patients who underwent polysomnography, 1 did not show sleep, 9 (69%) had poorly formed or absent sleep spindles and/or K-complexes, and 10 (77%) had sleep-disordered breathing. Of the 8 patients who experienced rapid eye movement (REM) sleep during the polysomnography, 3 (38%) showed REM sleep without atonia, and 2 patients met criteria for REM sleep behavior disorder. Median total sleep time was 226 (interquartile range [IQR] = 195-282) min. Median sleep efficiency was 58.5% (IQR = 41-65.5 %). Median REM time was 0.35% (IQR = 0-7.125%). Five patients (38%) demonstrated periodic limb movements during polysomnography. One case is presented. Conclusions: Sleep pathology is common in CJD, and screening for sleep pathology is indicated in the evaluation of patients with rapidly progressive dementias. Early identification and treatment of sleep pathology may provide an intervenable target for CJD.

AB - Study Objectives: Associations between sleep and neurodegenerative diseases have become increasingly evident. This study aims to characterize the prevalence and type of sleep pathology in Creutzfeldt-Jakob disease (CJD), a rapidly progressive, fatal neurodegenerative disease. Methods: In this observational cross-sectional cohort study, we performed a retrospective analysis of sleep signs and symptoms in a consecutive group of patients with definite CJD at a tertiary care medical center (n = 28). Polysomnography was performed in 14 patients. Results: Although only 5 of 28 patients carried a premorbid sleep diagnosis, signs/symptoms of sleep pathology were present in 25 patients. Eleven reported hypersomnia whereas 13 reported insomnia. Seven had restless legs symptoms and/or periodic limb movements of sleep, and nine reported parasomnias. Of the 14 patients who underwent polysomnography, 1 did not show sleep, 9 (69%) had poorly formed or absent sleep spindles and/or K-complexes, and 10 (77%) had sleep-disordered breathing. Of the 8 patients who experienced rapid eye movement (REM) sleep during the polysomnography, 3 (38%) showed REM sleep without atonia, and 2 patients met criteria for REM sleep behavior disorder. Median total sleep time was 226 (interquartile range [IQR] = 195-282) min. Median sleep efficiency was 58.5% (IQR = 41-65.5 %). Median REM time was 0.35% (IQR = 0-7.125%). Five patients (38%) demonstrated periodic limb movements during polysomnography. One case is presented. Conclusions: Sleep pathology is common in CJD, and screening for sleep pathology is indicated in the evaluation of patients with rapidly progressive dementias. Early identification and treatment of sleep pathology may provide an intervenable target for CJD.

KW - Creutzfeldt-Jakob disease

KW - Dementia

KW - Neurodegeneration

KW - Prion diseases

KW - Sleep disorders

UR - http://www.scopus.com/inward/record.url?scp=84979986792&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84979986792&partnerID=8YFLogxK

U2 - 10.5664/jcsm.5944

DO - 10.5664/jcsm.5944

M3 - Article

C2 - 27250807

AN - SCOPUS:84979986792

VL - 12

SP - 1033

EP - 1039

JO - Journal of Clinical Sleep Medicine

JF - Journal of Clinical Sleep Medicine

SN - 1550-9389

IS - 7

ER -