TY - JOUR
T1 - Sleep duration and bone health measures in older men
AU - for The Osteoporotic Fractures in Men (MrOS) Study
AU - Swanson, C. M.
AU - Blatchford, P. J.
AU - Stone, K. L.
AU - Cauley, J. A.
AU - Lane, N. E.
AU - Rogers-Soeder, T. S.
AU - Redline, S.
AU - Bauer, D. C.
AU - Wright, K. P.
AU - Wierman, M. E.
AU - Kohrt, W. M.
AU - Orwoll, E. S.
N1 - Funding Information:
KPW received support from NIH grants R01 HL135598, R01 HL131458, R01 HD087707, R01 DK114272, R01 DK115502, U01 HL150596, a Pac-12 Grant Application, and ONR MURI N00014-15-1-2809 during the time of this research.
Funding Information:
The Osteoporotic Fractures in Men (MrOS) Study is supported by NIH funding via the following institutes: the National Institute on Aging (NIA), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Center for Advancing Translational Sciences (NCATS), and NIH Roadmap for Medical Research, under the following grant numbers: U01AG027810, U01AG042124, U01AG042139, U01AG042140, U01 AG042143, U01 AG042145, U01 AG042168, and U01 AR066160.
Funding Information:
The National Heart, Lung, and Blood Institute (NHLBI) provides funding for the MrOS Sleep ancillary study “Outcomes of Sleep Disorders in Older Men” under the following grant numbers: R01 HL071194, R01 HL070848, R01 HL070847, R01 HL070842, R01 HL070841, R01 HL070837, R01 HL070838, and R01 HL070839. The National Institute on Aging (NIA) provided funding for vitamin D and melatonin assays under R01 AG030089
Funding Information:
SR was partially supported by NIH HL R35 135818.
Funding Information:
Research reported in this publication was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number 1K23AR070275, the Eastern Colorado VA Geriatric, Research, Education, and Clinical Center (GRECC), and the funding sources for the MrOS and MrOS Sleep Studies (as below). The contents do not represent the views of the US Department of Veterans Affairs or the United States Government. This research is also supported by NIH/NCATS Oregon Health and Science University CTSA Grant Number UL1 TR000128 and NIH/NCATS Colorado CTSA Grant Number UL1 TR002535. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Funding Information:
In the interest of full disclosure, we report the following; however, we do not believe any of these pertain to the current work. CMS, PJB, JAC, NEL, TSRS, DCB, MEW, WMK have nothing to disclose. KLS has received grant funding from Merck. SR has received consulting fees from Jazz Pharma, Respircardia and Eisa Inc and grant support from Jazz Pharma (unrelated to this paper). KPW reports research support from the NIH, Office of Naval Research, Pac-12; Financial relationships: consulting fees Circadian Therapeutics, LTD., Circadian Biotherapies, Philips Respironics. Board of Directors: Sleep Research Society. ESO has received research support from or consulting for Amgen, Mereo and Bayer.
Funding Information:
CMS was supported by NIH grant T32DK007674-20, NIH grant T32DK007446-34, and NIH grant K23AR070275.
Publisher Copyright:
© 2020, International Osteoporosis Foundation and National Osteoporosis Foundation.
PY - 2021/3
Y1 - 2021/3
N2 - Summary: The associations between objective measures of sleep duration and bone outcomes in older men are unknown. No consistent, significant association was identified between sleep duration and bone mineral density (BMD) in the current analysis. However, future research should determine if vitamin D status modifies this relationship. Introduction: Prior studies, predominantly in women, reported that long and short self-reported sleep duration are associated with lower BMD. Associations between actigraphy-determined sleep duration and BMD or bone turnover markers (BTMs) in older men are unknown. Methods: Men in The Osteoporotic Fractures in Men (MrOS) Study with wrist actigraphy and concurrent BMD assessment but without comorbidities affecting bone health were included. Sleep duration was considered as a continuous (N = 1926) and dichotomized variable where men were classified as getting the recommended (7–8 h/night; N = 478) or short (< 6 h/night; N = 577) sleep. The cross-sectional association between BMD, BTMs, and sleep duration was examined using a t test or linear regression, where appropriate, in unadjusted and adjusted models. Results: There were no clinically or statistically significant differences in BMD at the L-spine, total hip, or femoral neck between men getting the recommended vs. short sleep duration, using actigraphy or self-reported sleep duration (all p ≥ 0.07). When sleep duration was considered as a continuous variable, femoral neck BMD was higher in men with longer self-reported sleep duration (β = 0.006 ±0.003, p = 0.02), but this was not significant after further adjustment. In men with low 25OHD (< 20 ng/mL), longer actigraphy-determined sleep duration was associated with higher total hip BMD (β = 0.016 ± 0.008; p = 0.04). Sleep duration and BTMs were not associated. Conclusion: Sleep duration was not associated with hip or L-spine BMD or BTMs in older men. Future research should determine if vitamin D status or other factors modify this relationship.
AB - Summary: The associations between objective measures of sleep duration and bone outcomes in older men are unknown. No consistent, significant association was identified between sleep duration and bone mineral density (BMD) in the current analysis. However, future research should determine if vitamin D status modifies this relationship. Introduction: Prior studies, predominantly in women, reported that long and short self-reported sleep duration are associated with lower BMD. Associations between actigraphy-determined sleep duration and BMD or bone turnover markers (BTMs) in older men are unknown. Methods: Men in The Osteoporotic Fractures in Men (MrOS) Study with wrist actigraphy and concurrent BMD assessment but without comorbidities affecting bone health were included. Sleep duration was considered as a continuous (N = 1926) and dichotomized variable where men were classified as getting the recommended (7–8 h/night; N = 478) or short (< 6 h/night; N = 577) sleep. The cross-sectional association between BMD, BTMs, and sleep duration was examined using a t test or linear regression, where appropriate, in unadjusted and adjusted models. Results: There were no clinically or statistically significant differences in BMD at the L-spine, total hip, or femoral neck between men getting the recommended vs. short sleep duration, using actigraphy or self-reported sleep duration (all p ≥ 0.07). When sleep duration was considered as a continuous variable, femoral neck BMD was higher in men with longer self-reported sleep duration (β = 0.006 ±0.003, p = 0.02), but this was not significant after further adjustment. In men with low 25OHD (< 20 ng/mL), longer actigraphy-determined sleep duration was associated with higher total hip BMD (β = 0.016 ± 0.008; p = 0.04). Sleep duration and BTMs were not associated. Conclusion: Sleep duration was not associated with hip or L-spine BMD or BTMs in older men. Future research should determine if vitamin D status or other factors modify this relationship.
KW - Actigraphy
KW - Bone mineral density (BMD)
KW - Bone turnover markers (BTMs)
KW - Older men
KW - Sleep duration
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U2 - 10.1007/s00198-020-05619-2
DO - 10.1007/s00198-020-05619-2
M3 - Article
C2 - 32930851
AN - SCOPUS:85091097560
VL - 32
SP - 515
EP - 527
JO - Osteoporosis International
JF - Osteoporosis International
SN - 0937-941X
IS - 3
ER -