Sleep disturbance, cytokines, and fatigue in women with ovarian cancer

Lauren Clevenger, Andrew Schrepf, Desire Christensen, Koenraad De Geest, David Bender, Amina Ahmed, Michael J. Goodheart, Frank Penedo, David M. Lubaroff, Anil K. Sood, Susan K. Lutgendorf

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Pro-inflammatory cytokines, such as interleukin-6 (IL-6), have been implicated in the underlying processes contributing to sleep regulation and fatigue. Despite evidence for sleep difficulties, fatigue, and elevations in IL-6 among women with ovarian cancer, the association between these symptoms and IL-6 has not been investigated. To address this knowledge gap, we examined relationships between sleep disturbance, fatigue, and plasma IL-6 in 136 women with ovarian cancer prior to surgery. These relationships were also examined in 63 of these women who were disease-free and not receiving chemotherapy one year post-diagnosis. At both time-points, higher levels of IL-6 were significantly associated with sleep disturbances (p

Original languageEnglish (US)
Pages (from-to)1037-1044
Number of pages8
JournalBrain, Behavior, and Immunity
Volume26
Issue number7
DOIs
StatePublished - Oct 2012
Externally publishedYes

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Ovarian Neoplasms
Fatigue
Interleukin-6
Sleep
Cytokines
Drug Therapy

Keywords

  • Cancer
  • Circadian rhythm
  • Fatigue
  • Interleukin-6
  • Ovarian cancer
  • Sickness behaviors
  • Sleep

ASJC Scopus subject areas

  • Immunology
  • Behavioral Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Clevenger, L., Schrepf, A., Christensen, D., De Geest, K., Bender, D., Ahmed, A., ... Lutgendorf, S. K. (2012). Sleep disturbance, cytokines, and fatigue in women with ovarian cancer. Brain, Behavior, and Immunity, 26(7), 1037-1044. https://doi.org/10.1016/j.bbi.2012.04.003

Sleep disturbance, cytokines, and fatigue in women with ovarian cancer. / Clevenger, Lauren; Schrepf, Andrew; Christensen, Desire; De Geest, Koenraad; Bender, David; Ahmed, Amina; Goodheart, Michael J.; Penedo, Frank; Lubaroff, David M.; Sood, Anil K.; Lutgendorf, Susan K.

In: Brain, Behavior, and Immunity, Vol. 26, No. 7, 10.2012, p. 1037-1044.

Research output: Contribution to journalArticle

Clevenger, L, Schrepf, A, Christensen, D, De Geest, K, Bender, D, Ahmed, A, Goodheart, MJ, Penedo, F, Lubaroff, DM, Sood, AK & Lutgendorf, SK 2012, 'Sleep disturbance, cytokines, and fatigue in women with ovarian cancer', Brain, Behavior, and Immunity, vol. 26, no. 7, pp. 1037-1044. https://doi.org/10.1016/j.bbi.2012.04.003
Clevenger, Lauren ; Schrepf, Andrew ; Christensen, Desire ; De Geest, Koenraad ; Bender, David ; Ahmed, Amina ; Goodheart, Michael J. ; Penedo, Frank ; Lubaroff, David M. ; Sood, Anil K. ; Lutgendorf, Susan K. / Sleep disturbance, cytokines, and fatigue in women with ovarian cancer. In: Brain, Behavior, and Immunity. 2012 ; Vol. 26, No. 7. pp. 1037-1044.
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