Sleep as a Therapeutic Target in the Aging Brain

Thierno M. Bah, James Goodman, Jeffrey Iliff

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Sleep is a behavioral phenomenon conserved among mammals and some invertebrates, yet the biological functions of sleep are still being elucidated. In humans, sleep time becomes shorter, more fragmented, and of poorer quality with advancing age. Epidemiologically, the development of age-related neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease is associated with pronounced sleep disruption, whereas emerging mechanistic studies suggest that sleep disruption may be causally linked to neurodegenerative pathology, suggesting that sleep may represent a key therapeutic target in the prevention of these conditions. In this review, we discuss the physiology of sleep, the pathophysiology of neurodegenerative disease, and the current literature supporting the relationship between sleep, aging, and neurodegenerative disease.

Original languageEnglish (US)
Pages (from-to)554-568
Number of pages15
JournalNeurotherapeutics
Volume16
Issue number3
DOIs
Publication statusPublished - Jul 15 2019

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Keywords

  • aging
  • Alzheimer’s disease
  • cognitive decline
  • dementia
  • Sleep
  • treatment

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)

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