Sleep and Circadian Rhythms in Survivors of Acute Respiratory Failure

Pei Lin Yang, Teresa M. Ward, Robert L. Burr, Vishesh K. Kapur, Susan M. McCurry, Michael V. Vitiello, Catherine L. Hough, Elizabeth C. Parsons

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Little is known about sleep and circadian rhythms in survivors of acute respiratory failure (ARF) after hospital discharge. Objectives: To examine sleep and rest-activity circadian rhythms in ARF survivors 3 months after hospital discharge, and to compare them with a community-dwelling population. Methods: Sleep diary, actigraphy data, and insomnia symptoms were collected in a pilot study of 14 ARF survivors. Rest-activity circadian rhythms were assessed with wrist actigraphy and sleep diary for 9 days, and were analyzed by cosinor and non-parametric circadian rhythm analysis. Results: All participants had remarkable actigraphic sleep fragmentation, 71.5% had subclinical or clinical insomnia symptoms. Compared to community-dwelling adults, this cohort had less stable rest-activity circadian rhythms (p < 0.001), and weaker circadian strength (p < 0.001). Conclusion: Insomnia and circadian disruption were common in ARF survivors. Sleep improvement and circadian rhythm regularity may be a promising approach to improve quality of life and daytime function after ARF.

Original languageEnglish (US)
Article number94
JournalFrontiers in Neurology
Volume11
DOIs
StatePublished - Feb 14 2020
Externally publishedYes

Keywords

  • actigraphy
  • acute respiratory distress syndrome
  • circadian rhythm
  • critical illness
  • sleep

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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