HAUTREIZUNGEN DURCH PROPYLENGLYKOL

Translated title of the contribution: Skin Irritation from propylene glycol

K. E. Andersen, Frances Storrs

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Propylene glycol is used in foods, medicine and cosmetics because it is a good solvent which has, simultaneously, moisture-regulating, antiseptic, and preservative effects. Propylene glycol may produce eczematous skin reactions of toxic and, more rarely, of allergic nature. Positive patch test reactions to propylene glycol are difficult to interpret. Allergic reactions may be confirmed by a clear clinical relevance, repeated local skin provocation (usage test), or oral provocation. In the Department of Dermatology, University of Oregon, 84 patients were patch tested with 100% propylene glycol. Five of 12 patch test-positive patients had allergic reactions while seven had irritant reactions. In the Department of Dermatology, Gentofte Hospital, 248 consecutive eczema patients were patch-tested with propylene glycol in concentrations of 100%, 20%, and 2% in water. Two of five patients with positive reactions to patch tests showed an itchy eczematous eruption after oral provocation with 15 ml propylene glycol. Skin reactions due to propylene glycol are rare and should not bring the preparation into unnecessary discredit. The possibility of propylene glycol allergy should be recognized by dermatologists as propylene glycol is used in local steroids and other topical preparations.

Original languageGerman
Pages (from-to)12-14
Number of pages3
JournalHautarzt
Volume33
Issue number1
StatePublished - 1982
Externally publishedYes

Fingerprint

Propylene Glycol
Skin
Patch Tests
Hypersensitivity
Dermatology
Local Anti-Infective Agents
Irritants
Poisons
Eczema
Cosmetics
Steroids
Medicine
Food
Water

ASJC Scopus subject areas

  • Dermatology

Cite this

Andersen, K. E., & Storrs, F. (1982). HAUTREIZUNGEN DURCH PROPYLENGLYKOL. Hautarzt, 33(1), 12-14.

HAUTREIZUNGEN DURCH PROPYLENGLYKOL. / Andersen, K. E.; Storrs, Frances.

In: Hautarzt, Vol. 33, No. 1, 1982, p. 12-14.

Research output: Contribution to journalArticle

Andersen, KE & Storrs, F 1982, 'HAUTREIZUNGEN DURCH PROPYLENGLYKOL', Hautarzt, vol. 33, no. 1, pp. 12-14.
Andersen, K. E. ; Storrs, Frances. / HAUTREIZUNGEN DURCH PROPYLENGLYKOL. In: Hautarzt. 1982 ; Vol. 33, No. 1. pp. 12-14.
@article{388b359098c44df99c84d44940b0abe1,
title = "HAUTREIZUNGEN DURCH PROPYLENGLYKOL",
abstract = "Propylene glycol is used in foods, medicine and cosmetics because it is a good solvent which has, simultaneously, moisture-regulating, antiseptic, and preservative effects. Propylene glycol may produce eczematous skin reactions of toxic and, more rarely, of allergic nature. Positive patch test reactions to propylene glycol are difficult to interpret. Allergic reactions may be confirmed by a clear clinical relevance, repeated local skin provocation (usage test), or oral provocation. In the Department of Dermatology, University of Oregon, 84 patients were patch tested with 100{\%} propylene glycol. Five of 12 patch test-positive patients had allergic reactions while seven had irritant reactions. In the Department of Dermatology, Gentofte Hospital, 248 consecutive eczema patients were patch-tested with propylene glycol in concentrations of 100{\%}, 20{\%}, and 2{\%} in water. Two of five patients with positive reactions to patch tests showed an itchy eczematous eruption after oral provocation with 15 ml propylene glycol. Skin reactions due to propylene glycol are rare and should not bring the preparation into unnecessary discredit. The possibility of propylene glycol allergy should be recognized by dermatologists as propylene glycol is used in local steroids and other topical preparations.",
author = "Andersen, {K. E.} and Frances Storrs",
year = "1982",
language = "German",
volume = "33",
pages = "12--14",
journal = "Der Hautarzt",
issn = "0017-8470",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - HAUTREIZUNGEN DURCH PROPYLENGLYKOL

AU - Andersen, K. E.

AU - Storrs, Frances

PY - 1982

Y1 - 1982

N2 - Propylene glycol is used in foods, medicine and cosmetics because it is a good solvent which has, simultaneously, moisture-regulating, antiseptic, and preservative effects. Propylene glycol may produce eczematous skin reactions of toxic and, more rarely, of allergic nature. Positive patch test reactions to propylene glycol are difficult to interpret. Allergic reactions may be confirmed by a clear clinical relevance, repeated local skin provocation (usage test), or oral provocation. In the Department of Dermatology, University of Oregon, 84 patients were patch tested with 100% propylene glycol. Five of 12 patch test-positive patients had allergic reactions while seven had irritant reactions. In the Department of Dermatology, Gentofte Hospital, 248 consecutive eczema patients were patch-tested with propylene glycol in concentrations of 100%, 20%, and 2% in water. Two of five patients with positive reactions to patch tests showed an itchy eczematous eruption after oral provocation with 15 ml propylene glycol. Skin reactions due to propylene glycol are rare and should not bring the preparation into unnecessary discredit. The possibility of propylene glycol allergy should be recognized by dermatologists as propylene glycol is used in local steroids and other topical preparations.

AB - Propylene glycol is used in foods, medicine and cosmetics because it is a good solvent which has, simultaneously, moisture-regulating, antiseptic, and preservative effects. Propylene glycol may produce eczematous skin reactions of toxic and, more rarely, of allergic nature. Positive patch test reactions to propylene glycol are difficult to interpret. Allergic reactions may be confirmed by a clear clinical relevance, repeated local skin provocation (usage test), or oral provocation. In the Department of Dermatology, University of Oregon, 84 patients were patch tested with 100% propylene glycol. Five of 12 patch test-positive patients had allergic reactions while seven had irritant reactions. In the Department of Dermatology, Gentofte Hospital, 248 consecutive eczema patients were patch-tested with propylene glycol in concentrations of 100%, 20%, and 2% in water. Two of five patients with positive reactions to patch tests showed an itchy eczematous eruption after oral provocation with 15 ml propylene glycol. Skin reactions due to propylene glycol are rare and should not bring the preparation into unnecessary discredit. The possibility of propylene glycol allergy should be recognized by dermatologists as propylene glycol is used in local steroids and other topical preparations.

UR - http://www.scopus.com/inward/record.url?scp=0020064127&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020064127&partnerID=8YFLogxK

M3 - Article

VL - 33

SP - 12

EP - 14

JO - Der Hautarzt

JF - Der Hautarzt

SN - 0017-8470

IS - 1

ER -