Skeletal muscles of ambulant children with Duchenne muscular dystrophy

Validation of multicenter study of evaluation with MR imaging and MR spectroscopy

Sean C. Forbes, Glenn A. Walter, William Rooney, Dah Jyuu Wang, Soren DeVos, Jim Pollaro, William Triplett, Donovan J. Lott, Rebecca J. Willcocks, Claudia Senesac, Michael J. Daniels, Barry J. Byrne, Barry Russman, Richard S. Finkel, James S. Meyer, H. Lee Sweeney, Krista Vandenborne

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Purpose: To validate a multicenter protocol that examines lower extremity skeletal muscles of children with Duchenne muscular dystrophy (DMD) by using magnetic resonance (MR) imaging and MR spectroscopy in terms of reproducibility of these measurements within and across centers. Materials and Methods: This HIPAA-compliant study was approved by the institutional review boards of all participating centers, and informed consent was obtained from each participant or a guardian. Standardized procedures with MR operator training and quality assurance assessments were implemented, and data were acquired at three centers by using different 3-T MR imaging instruments. Measures of maximal cross-sectional area (CSAmax), transverse relaxation time constant (T2), and lipid fraction were compared among centers in two-compartment coaxial phantoms and in two unaffected adult subjects who visited each center. Also, repeat MR measures were acquired twice on separate days in 30 boys with DMD (10 per center) and 10 unaffected boys. Coefficients of variation (CVs) were computed to examine the repeated-measure variabilities within and across centers. Results: CSAmax, T2 from MR imaging and MR spectroscopy, and lipid fraction were consistent across centers in the phantom (CV, max, CV = 3.7% [25th percentile, 1.3%; 75th percentile, 5.1%]; contractile area, CV = 4.2% [25th percentile, 0.8%; 75th percentile, 4.9%]; MR imaging T2, CV = 3.1% [25th percentile, 1.2%; 75th percentile, 4.7%]; MR spectroscopy T2, CV = 3.9% [25th percentile, 1.5%; 75th percentile, 5.1%]; and lipid fraction, CV = 4.7% [25th percentile, 1.0%; 75th percentile, 5.3%]). Conclusion: The MR protocol implemented in this multicenter study achieved highly reproducible measures of lower extremity muscles across centers and from day to day in ambulatory boys with DMD.

Original languageEnglish (US)
Pages (from-to)198-207
Number of pages10
JournalRadiology
Volume269
Issue number1
DOIs
StatePublished - Oct 2013

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Duchenne Muscular Dystrophy
Validation Studies
Multicenter Studies
Skeletal Muscle
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Lipids
Lower Extremity
Health Insurance Portability and Accountability Act
Research Ethics Committees
Informed Consent
Muscles

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Skeletal muscles of ambulant children with Duchenne muscular dystrophy : Validation of multicenter study of evaluation with MR imaging and MR spectroscopy. / Forbes, Sean C.; Walter, Glenn A.; Rooney, William; Wang, Dah Jyuu; DeVos, Soren; Pollaro, Jim; Triplett, William; Lott, Donovan J.; Willcocks, Rebecca J.; Senesac, Claudia; Daniels, Michael J.; Byrne, Barry J.; Russman, Barry; Finkel, Richard S.; Meyer, James S.; Sweeney, H. Lee; Vandenborne, Krista.

In: Radiology, Vol. 269, No. 1, 10.2013, p. 198-207.

Research output: Contribution to journalArticle

Forbes, SC, Walter, GA, Rooney, W, Wang, DJ, DeVos, S, Pollaro, J, Triplett, W, Lott, DJ, Willcocks, RJ, Senesac, C, Daniels, MJ, Byrne, BJ, Russman, B, Finkel, RS, Meyer, JS, Sweeney, HL & Vandenborne, K 2013, 'Skeletal muscles of ambulant children with Duchenne muscular dystrophy: Validation of multicenter study of evaluation with MR imaging and MR spectroscopy', Radiology, vol. 269, no. 1, pp. 198-207. https://doi.org/10.1148/radiol.13121948
Forbes, Sean C. ; Walter, Glenn A. ; Rooney, William ; Wang, Dah Jyuu ; DeVos, Soren ; Pollaro, Jim ; Triplett, William ; Lott, Donovan J. ; Willcocks, Rebecca J. ; Senesac, Claudia ; Daniels, Michael J. ; Byrne, Barry J. ; Russman, Barry ; Finkel, Richard S. ; Meyer, James S. ; Sweeney, H. Lee ; Vandenborne, Krista. / Skeletal muscles of ambulant children with Duchenne muscular dystrophy : Validation of multicenter study of evaluation with MR imaging and MR spectroscopy. In: Radiology. 2013 ; Vol. 269, No. 1. pp. 198-207.
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abstract = "Purpose: To validate a multicenter protocol that examines lower extremity skeletal muscles of children with Duchenne muscular dystrophy (DMD) by using magnetic resonance (MR) imaging and MR spectroscopy in terms of reproducibility of these measurements within and across centers. Materials and Methods: This HIPAA-compliant study was approved by the institutional review boards of all participating centers, and informed consent was obtained from each participant or a guardian. Standardized procedures with MR operator training and quality assurance assessments were implemented, and data were acquired at three centers by using different 3-T MR imaging instruments. Measures of maximal cross-sectional area (CSAmax), transverse relaxation time constant (T2), and lipid fraction were compared among centers in two-compartment coaxial phantoms and in two unaffected adult subjects who visited each center. Also, repeat MR measures were acquired twice on separate days in 30 boys with DMD (10 per center) and 10 unaffected boys. Coefficients of variation (CVs) were computed to examine the repeated-measure variabilities within and across centers. Results: CSAmax, T2 from MR imaging and MR spectroscopy, and lipid fraction were consistent across centers in the phantom (CV, max, CV = 3.7{\%} [25th percentile, 1.3{\%}; 75th percentile, 5.1{\%}]; contractile area, CV = 4.2{\%} [25th percentile, 0.8{\%}; 75th percentile, 4.9{\%}]; MR imaging T2, CV = 3.1{\%} [25th percentile, 1.2{\%}; 75th percentile, 4.7{\%}]; MR spectroscopy T2, CV = 3.9{\%} [25th percentile, 1.5{\%}; 75th percentile, 5.1{\%}]; and lipid fraction, CV = 4.7{\%} [25th percentile, 1.0{\%}; 75th percentile, 5.3{\%}]). Conclusion: The MR protocol implemented in this multicenter study achieved highly reproducible measures of lower extremity muscles across centers and from day to day in ambulatory boys with DMD.",
author = "Forbes, {Sean C.} and Walter, {Glenn A.} and William Rooney and Wang, {Dah Jyuu} and Soren DeVos and Jim Pollaro and William Triplett and Lott, {Donovan J.} and Willcocks, {Rebecca J.} and Claudia Senesac and Daniels, {Michael J.} and Byrne, {Barry J.} and Barry Russman and Finkel, {Richard S.} and Meyer, {James S.} and Sweeney, {H. Lee} and Krista Vandenborne",
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T1 - Skeletal muscles of ambulant children with Duchenne muscular dystrophy

T2 - Validation of multicenter study of evaluation with MR imaging and MR spectroscopy

AU - Forbes, Sean C.

AU - Walter, Glenn A.

AU - Rooney, William

AU - Wang, Dah Jyuu

AU - DeVos, Soren

AU - Pollaro, Jim

AU - Triplett, William

AU - Lott, Donovan J.

AU - Willcocks, Rebecca J.

AU - Senesac, Claudia

AU - Daniels, Michael J.

AU - Byrne, Barry J.

AU - Russman, Barry

AU - Finkel, Richard S.

AU - Meyer, James S.

AU - Sweeney, H. Lee

AU - Vandenborne, Krista

PY - 2013/10

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N2 - Purpose: To validate a multicenter protocol that examines lower extremity skeletal muscles of children with Duchenne muscular dystrophy (DMD) by using magnetic resonance (MR) imaging and MR spectroscopy in terms of reproducibility of these measurements within and across centers. Materials and Methods: This HIPAA-compliant study was approved by the institutional review boards of all participating centers, and informed consent was obtained from each participant or a guardian. Standardized procedures with MR operator training and quality assurance assessments were implemented, and data were acquired at three centers by using different 3-T MR imaging instruments. Measures of maximal cross-sectional area (CSAmax), transverse relaxation time constant (T2), and lipid fraction were compared among centers in two-compartment coaxial phantoms and in two unaffected adult subjects who visited each center. Also, repeat MR measures were acquired twice on separate days in 30 boys with DMD (10 per center) and 10 unaffected boys. Coefficients of variation (CVs) were computed to examine the repeated-measure variabilities within and across centers. Results: CSAmax, T2 from MR imaging and MR spectroscopy, and lipid fraction were consistent across centers in the phantom (CV, max, CV = 3.7% [25th percentile, 1.3%; 75th percentile, 5.1%]; contractile area, CV = 4.2% [25th percentile, 0.8%; 75th percentile, 4.9%]; MR imaging T2, CV = 3.1% [25th percentile, 1.2%; 75th percentile, 4.7%]; MR spectroscopy T2, CV = 3.9% [25th percentile, 1.5%; 75th percentile, 5.1%]; and lipid fraction, CV = 4.7% [25th percentile, 1.0%; 75th percentile, 5.3%]). Conclusion: The MR protocol implemented in this multicenter study achieved highly reproducible measures of lower extremity muscles across centers and from day to day in ambulatory boys with DMD.

AB - Purpose: To validate a multicenter protocol that examines lower extremity skeletal muscles of children with Duchenne muscular dystrophy (DMD) by using magnetic resonance (MR) imaging and MR spectroscopy in terms of reproducibility of these measurements within and across centers. Materials and Methods: This HIPAA-compliant study was approved by the institutional review boards of all participating centers, and informed consent was obtained from each participant or a guardian. Standardized procedures with MR operator training and quality assurance assessments were implemented, and data were acquired at three centers by using different 3-T MR imaging instruments. Measures of maximal cross-sectional area (CSAmax), transverse relaxation time constant (T2), and lipid fraction were compared among centers in two-compartment coaxial phantoms and in two unaffected adult subjects who visited each center. Also, repeat MR measures were acquired twice on separate days in 30 boys with DMD (10 per center) and 10 unaffected boys. Coefficients of variation (CVs) were computed to examine the repeated-measure variabilities within and across centers. Results: CSAmax, T2 from MR imaging and MR spectroscopy, and lipid fraction were consistent across centers in the phantom (CV, max, CV = 3.7% [25th percentile, 1.3%; 75th percentile, 5.1%]; contractile area, CV = 4.2% [25th percentile, 0.8%; 75th percentile, 4.9%]; MR imaging T2, CV = 3.1% [25th percentile, 1.2%; 75th percentile, 4.7%]; MR spectroscopy T2, CV = 3.9% [25th percentile, 1.5%; 75th percentile, 5.1%]; and lipid fraction, CV = 4.7% [25th percentile, 1.0%; 75th percentile, 5.3%]). Conclusion: The MR protocol implemented in this multicenter study achieved highly reproducible measures of lower extremity muscles across centers and from day to day in ambulatory boys with DMD.

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