TY - JOUR
T1 - SK channels in excitability, pacemaking and synaptic integration
AU - Bond, Chris T.
AU - Maylie, James
AU - Adelman, John P.
N1 - Funding Information:
We thank L Vaskalis for expert graphics assistance, and patience. We also thank all of our colleagues in this exciting field for their enthusiasm and interactions. We are supported by grants from the National Institutes of Health.
PY - 2005/6
Y1 - 2005/6
N2 - Small conductance calcium-activated potassium channels link elevations of intracellular calcium ions to membrane potential, exerting a hyperpolarizing influence when activated. The consequences of SK channel activity have been revealed by the specific blocker apamin, a peptide toxin from honeybee venom. Recent studies have revealed unexpected roles for SK channels in fine-tuning intrinsic cell firing properties and in responsiveness to synaptic input. They have also identified specific roles for different SK channel subtypes. A host of Ca2+ sources, including distinct subtypes of voltage-dependent calcium channels, intracellular Ca2+ stores and Ca 2+-permeable ionotropic neurotransmitter receptors, activate SK channels. The macromolecular complex in which the Ca2+ source, SK channels and various modulators are assembled determines the kinetics and consequences of SK channel activation.
AB - Small conductance calcium-activated potassium channels link elevations of intracellular calcium ions to membrane potential, exerting a hyperpolarizing influence when activated. The consequences of SK channel activity have been revealed by the specific blocker apamin, a peptide toxin from honeybee venom. Recent studies have revealed unexpected roles for SK channels in fine-tuning intrinsic cell firing properties and in responsiveness to synaptic input. They have also identified specific roles for different SK channel subtypes. A host of Ca2+ sources, including distinct subtypes of voltage-dependent calcium channels, intracellular Ca2+ stores and Ca 2+-permeable ionotropic neurotransmitter receptors, activate SK channels. The macromolecular complex in which the Ca2+ source, SK channels and various modulators are assembled determines the kinetics and consequences of SK channel activation.
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U2 - 10.1016/j.conb.2005.05.001
DO - 10.1016/j.conb.2005.05.001
M3 - Review article
C2 - 15922588
AN - SCOPUS:20444391728
VL - 15
SP - 305
EP - 311
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
SN - 0959-4388
IS - 3 SPEC. ISS.
ER -