Abstract
Small conductance calcium-activated potassium channels link elevations of intracellular calcium ions to membrane potential, exerting a hyperpolarizing influence when activated. The consequences of SK channel activity have been revealed by the specific blocker apamin, a peptide toxin from honeybee venom. Recent studies have revealed unexpected roles for SK channels in fine-tuning intrinsic cell firing properties and in responsiveness to synaptic input. They have also identified specific roles for different SK channel subtypes. A host of Ca2+ sources, including distinct subtypes of voltage-dependent calcium channels, intracellular Ca2+ stores and Ca 2+-permeable ionotropic neurotransmitter receptors, activate SK channels. The macromolecular complex in which the Ca2+ source, SK channels and various modulators are assembled determines the kinetics and consequences of SK channel activation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 305-311 |
| Number of pages | 7 |
| Journal | Current Opinion in Neurobiology |
| Volume | 15 |
| Issue number | 3 SPEC. ISS. |
| DOIs | |
| State | Published - Jun 2005 |
Fingerprint
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
SK channels in excitability, pacemaking and synaptic integration. / Bond, Chris T.; Maylie, James; Adelman, John.
In: Current Opinion in Neurobiology, Vol. 15, No. 3 SPEC. ISS., 06.2005, p. 305-311.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - SK channels in excitability, pacemaking and synaptic integration
AU - Bond, Chris T.
AU - Maylie, James
AU - Adelman, John
PY - 2005/6
Y1 - 2005/6
N2 - Small conductance calcium-activated potassium channels link elevations of intracellular calcium ions to membrane potential, exerting a hyperpolarizing influence when activated. The consequences of SK channel activity have been revealed by the specific blocker apamin, a peptide toxin from honeybee venom. Recent studies have revealed unexpected roles for SK channels in fine-tuning intrinsic cell firing properties and in responsiveness to synaptic input. They have also identified specific roles for different SK channel subtypes. A host of Ca2+ sources, including distinct subtypes of voltage-dependent calcium channels, intracellular Ca2+ stores and Ca 2+-permeable ionotropic neurotransmitter receptors, activate SK channels. The macromolecular complex in which the Ca2+ source, SK channels and various modulators are assembled determines the kinetics and consequences of SK channel activation.
AB - Small conductance calcium-activated potassium channels link elevations of intracellular calcium ions to membrane potential, exerting a hyperpolarizing influence when activated. The consequences of SK channel activity have been revealed by the specific blocker apamin, a peptide toxin from honeybee venom. Recent studies have revealed unexpected roles for SK channels in fine-tuning intrinsic cell firing properties and in responsiveness to synaptic input. They have also identified specific roles for different SK channel subtypes. A host of Ca2+ sources, including distinct subtypes of voltage-dependent calcium channels, intracellular Ca2+ stores and Ca 2+-permeable ionotropic neurotransmitter receptors, activate SK channels. The macromolecular complex in which the Ca2+ source, SK channels and various modulators are assembled determines the kinetics and consequences of SK channel activation.
UR - http://www.scopus.com/inward/record.url?scp=20444391728&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20444391728&partnerID=8YFLogxK
U2 - 10.1016/j.conb.2005.05.001
DO - 10.1016/j.conb.2005.05.001
M3 - Article
C2 - 15922588
AN - SCOPUS:20444391728
VL - 15
SP - 305
EP - 311
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
SN - 0959-4388
IS - 3 SPEC. ISS.
ER -