SK channels and calmodulin

John Adelman

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Calcium ions are Nature’s most widely used signaling mechanism, mediating communication between pathways at virtually every physiological level. Ion channels are no exception, as the activities of a wide range of ion channels are intricately shaped by fluctuations in intracellular Ca2+ levels. Mirroring the importance and the breadth of Ca2+ signaling, free Ca2+ levels are tightly controlled, and a myriad of Ca2+ binding proteins transduce Ca2+ signals, each with its own nuance, comprising a constantly changing symphony of metabolic activity. The founding member of Ca2+ binding proteins is calmodulin (CaM), a small, acidic, modular protein endowed with gymnastic-like flexibility and E-F hand motifs that chelate Ca2+ ions. In this review, I will trace the history that led to the realization that CaM serves as the Ca2+-gating cue for SK channels, the experiments that revealed that CaM is an intrinsic subunit of SK channels, and itself a target of regulation.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalChannels
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Calmodulin
Ion Channels
Ions
Calmodulin-Binding Proteins
Gymnastics
Carrier Proteins
Cues
Hand
History
Communication
Calcium
Proteins
Experiments

Keywords

  • Ca-gating
  • Calmodulin
  • Curing
  • E-F hands
  • Intrinsic subunit
  • Paramecium
  • SK channel

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics

Cite this

SK channels and calmodulin. / Adelman, John.

In: Channels, Vol. 10, No. 1, 01.01.2016, p. 1-6.

Research output: Contribution to journalArticle

Adelman, John. / SK channels and calmodulin. In: Channels. 2016 ; Vol. 10, No. 1. pp. 1-6.
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