Sixty-Five Years of Sympathetic Ophthalmia

A Clinicopathologic Review of 105, Cases (1913–1978)

Jane R. Lubin, Daniel Albert, Miriam Weinstein

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

A retrospective clinicopathologic review of 105 cases of sympathetic ophthalmia showed histologic features of prognostic significance and evaluated the role of therapy. Classic descriptions omit retinal changes, but 58.0% of our cases had retinal detachment and 42.2% showed intraretinal inflammation. The optic nerve and/or meninges were inflamed in 51%. Optic atrophy was seen in 54.4%. Plasma cells are said to be characteristically absent, but 65.0% of steroid-treated and 85.7% of cases before the steroid era showed plasma cell infiltration. Severity of inflammation pathologically correlated with final visual outcome, and corticosteroid therapy changed both the character and severity of inflammation. Early enucleation of the exciting eye after onset of symptoms in the fellow eye was found to improve visual prognosis. Electron microscopy performed on fresh tissue and choroidal cell cultures revealed no viral particles, and viral and mycoplasma cultures all proved negative.

Original languageEnglish (US)
Pages (from-to)109-121
Number of pages13
JournalOphthalmology
Volume87
Issue number2
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

Fingerprint

Sympathetic Ophthalmia
Plasma Cells
Inflammation
Steroids
Eye Enucleation
Optic Atrophy
Meninges
Mycoplasma
Retinal Detachment
Optic Nerve
Virion
Electron Microscopy
Adrenal Cortex Hormones
Cell Culture Techniques
Therapeutics

Keywords

  • granulomatous inflammation
  • phacoanaphylaxis
  • sympathetic ophthalmia
  • uveitis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Sixty-Five Years of Sympathetic Ophthalmia : A Clinicopathologic Review of 105, Cases (1913–1978). / Lubin, Jane R.; Albert, Daniel; Weinstein, Miriam.

In: Ophthalmology, Vol. 87, No. 2, 01.01.1980, p. 109-121.

Research output: Contribution to journalArticle

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