Six-year results of a randomized, prospective trial of human growth hormone and oxandrolone in Turner syndrome

Ronald (Ron) Rosenfeld, James France, Kenneth M. Attie, Jo Anne Brasel, Stephen Burstein, Jose F. Cara, Steven Chernausek, Ronald W. Gotlin, Joyce Kuntze, Barbara M. Lippe, Patrick C. Mahoney, Wayne V. Moore, Paul Saenger, Ann J. Johanson

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

Seventy girls with Turner syndrome, verified by karyotype, were randomly assigned to observation or treatment with human growth hormone (hGH), oxandrolone, or a combination of hGH plus oxandrolone for a period of 12 to 24 months, to assess the effect of treatment on growth velocity and adult height. Subsequently, all subjects received either hGH alone or hGH plus oxandrolone. Data are presented for 62 subjects treated for a period of 3 to 6 years. When compared with the anticipated growth rate in untreated patients, the growth rate after treatment with hGH, both alone and in combination with oxandrolone, showed a sustained increase for at least 6 years. Treatment is continuing in over half of the subjects; at present, 14 (82%) of 17 girls receiving hGH alone and 41 (91%) of 45 girls receiving combination therapy exceeded their expected adult heights. Thirty girls have completed treatment; mean height for these 30 patients is 151.9 cm, compared with their mean original projected adult height of 143.8 cm. We conclude that therapy with hGH, alone and in combination with oxandrolone, can result in a sustained increase in growth rate and a significant increase in adult height for most prepubertal girls with Turner syndrome.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalThe Journal of Pediatrics
Volume121
Issue number1
DOIs
StatePublished - 1992
Externally publishedYes

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Oxandrolone
Turner Syndrome
Human Growth Hormone
Growth
Therapeutics
Karyotype
Observation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Rosenfeld, R. R., France, J., Attie, K. M., Brasel, J. A., Burstein, S., Cara, J. F., ... Johanson, A. J. (1992). Six-year results of a randomized, prospective trial of human growth hormone and oxandrolone in Turner syndrome. The Journal of Pediatrics, 121(1), 49-55. https://doi.org/10.1016/S0022-3476(05)82540-5

Six-year results of a randomized, prospective trial of human growth hormone and oxandrolone in Turner syndrome. / Rosenfeld, Ronald (Ron); France, James; Attie, Kenneth M.; Brasel, Jo Anne; Burstein, Stephen; Cara, Jose F.; Chernausek, Steven; Gotlin, Ronald W.; Kuntze, Joyce; Lippe, Barbara M.; Mahoney, Patrick C.; Moore, Wayne V.; Saenger, Paul; Johanson, Ann J.

In: The Journal of Pediatrics, Vol. 121, No. 1, 1992, p. 49-55.

Research output: Contribution to journalArticle

Rosenfeld, RR, France, J, Attie, KM, Brasel, JA, Burstein, S, Cara, JF, Chernausek, S, Gotlin, RW, Kuntze, J, Lippe, BM, Mahoney, PC, Moore, WV, Saenger, P & Johanson, AJ 1992, 'Six-year results of a randomized, prospective trial of human growth hormone and oxandrolone in Turner syndrome', The Journal of Pediatrics, vol. 121, no. 1, pp. 49-55. https://doi.org/10.1016/S0022-3476(05)82540-5
Rosenfeld, Ronald (Ron) ; France, James ; Attie, Kenneth M. ; Brasel, Jo Anne ; Burstein, Stephen ; Cara, Jose F. ; Chernausek, Steven ; Gotlin, Ronald W. ; Kuntze, Joyce ; Lippe, Barbara M. ; Mahoney, Patrick C. ; Moore, Wayne V. ; Saenger, Paul ; Johanson, Ann J. / Six-year results of a randomized, prospective trial of human growth hormone and oxandrolone in Turner syndrome. In: The Journal of Pediatrics. 1992 ; Vol. 121, No. 1. pp. 49-55.
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