SIV infection of rhesus macaques of Chinese origin: A suitable model for HIV infection in humans

Yu Zhou, Rong Bao, Nancy L. Haigwood, Yuri Persidsky, Wen zhe Ho

    Research output: Contribution to journalReview article

    32 Scopus citations

    Abstract

    Simian immunodeficiency virus (SIV) infection of Indian-origin rhesus macaques (RM) has been widely used as a well-established nonhuman primate (NHP) model for HIV/AIDS research. However, there have been a growing number of studies using Chinese RM to evaluate immunopathogenesis of SIV infection. In this paper, we have for the first time reviewed and discussed the major publications related to SIV or SHIV infection of Chinese RM in the past decades. We have compared the differences in the pathogenesis of SIV infection between Chinese RM and Indian RM with regard to viral infection, immunological response, and host genetic background. Given AIDS is a disease that affects humans of diverse origins, it is of importance to study animals with different geographical background. Therefore, to examine and compare results obtained from RM models of Indian and Chinese origins should lead to further validation and improvement of these animal models for HIV/AIDS research.

    Original languageEnglish (US)
    Article number89
    JournalRetrovirology
    Volume10
    Issue number1
    DOIs
    StatePublished - Aug 15 2013

    Keywords

    • Chinese rhesus macaques (RM)
    • HIV/AIDS
    • Indian RM
    • Nonhuman primate (NHP)
    • Simian immunodeficiency virus (SIV)

    ASJC Scopus subject areas

    • Virology
    • Infectious Diseases

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