SIV envelope glycoprotein epitopes recognized by antibodies from infected or vaccinated rhesus macaques.

J. V. Torres, D. E. Anderson, A. Malley, B. Banapour, Michael Axthelm, E. Benjamini, M. B. Gardner

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We analyzed SIV-specific monkey sera to localize B-cell epitopes of the envelope glycoprotein of SIV (gp130), using overlapping synthetic peptides representing the entire SIV gp130 protein and sera from experimentally infected monkeys and monkeys immunized with whole, inactivated SIV. A B-cell epitope which induces neutralizing antibody production and T-cell responses was characterized as well as a new B-cell epitope and a previously described neutralizing epitopes. Vaccinated monkey sera recognize the three epitopes differentially relative to unimmunized controls, and a correlation appears to exist between degree of cross-neutralization by infected monkey sera and degree of binding to these three regions.

Original languageEnglish (US)
Pages (from-to)129-137
Number of pages9
JournalJournal of Medical Primatology
Volume22
Issue number2-3
StatePublished - Feb 1993
Externally publishedYes

Fingerprint

Macaca mulatta
epitopes
Haplorhini
monkeys
glycoproteins
Epitopes
Glycoproteins
B-Lymphocyte Epitopes
antibodies
Antibodies
B-lymphocytes
neutralization
Serum
synthetic peptides
antibody formation
Neutralizing Antibodies
neutralizing antibodies
Antibody Formation
Blood Proteins
T-lymphocytes

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Torres, J. V., Anderson, D. E., Malley, A., Banapour, B., Axthelm, M., Benjamini, E., & Gardner, M. B. (1993). SIV envelope glycoprotein epitopes recognized by antibodies from infected or vaccinated rhesus macaques. Journal of Medical Primatology, 22(2-3), 129-137.

SIV envelope glycoprotein epitopes recognized by antibodies from infected or vaccinated rhesus macaques. / Torres, J. V.; Anderson, D. E.; Malley, A.; Banapour, B.; Axthelm, Michael; Benjamini, E.; Gardner, M. B.

In: Journal of Medical Primatology, Vol. 22, No. 2-3, 02.1993, p. 129-137.

Research output: Contribution to journalArticle

Torres, JV, Anderson, DE, Malley, A, Banapour, B, Axthelm, M, Benjamini, E & Gardner, MB 1993, 'SIV envelope glycoprotein epitopes recognized by antibodies from infected or vaccinated rhesus macaques.', Journal of Medical Primatology, vol. 22, no. 2-3, pp. 129-137.
Torres, J. V. ; Anderson, D. E. ; Malley, A. ; Banapour, B. ; Axthelm, Michael ; Benjamini, E. ; Gardner, M. B. / SIV envelope glycoprotein epitopes recognized by antibodies from infected or vaccinated rhesus macaques. In: Journal of Medical Primatology. 1993 ; Vol. 22, No. 2-3. pp. 129-137.
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