Sirtuin (SIRT)-1: At the crossroads of puberty and metabolism

Carlos F. Aylwin, Alejandro Lomniczi

    Research output: Contribution to journalReview articlepeer-review

    Abstract

    In the arcuate nucleus of the hypothalamus reside two neuronal systems in charge of regulating feeding control and reproductive development. The melanocortin system responds to metabolic fluctuations adjusting food intake, whereas kisspeptin neurons are in charge of the excitatory control of gonadotropin hormone–releasing hormone (GnRH) neurons. While it is known that the melanocortin system regulates GnRH neuronal activity, it was recently demonstrated that kisspeptin neurons not only innervate melanocortin neurons but also play an active role in the control of metabolism. These two neuronal systems are intricately interconnected forming loops of stimulation and inhibition according to metabolic status. Furthermore, intracellular and epigenetic pathways respond to external environmental signals by changing DNA conformation and gene expression. Here, we review the role of silent mating type information regulation 2 homolog 1, a class III nicotinamide adenine dinucleotide–dependent protein deacetylase, in the arcuate nucleus control of pubertal development and feeding behavior.

    Original languageEnglish (US)
    Pages (from-to)65-72
    Number of pages8
    JournalCurrent Opinion in Endocrine and Metabolic Research
    Volume14
    DOIs
    StatePublished - Oct 2020

    Keywords

    • Arcuate nucleus
    • Chromatin modifications
    • GnRH
    • Kisspeptin
    • Melanocortin
    • Polycomb group
    • Puberty
    • Transcriptional activation
    • Transcriptional repression
    • Trithorax complex

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism

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