Sinonasal disease in patients with sarcoidosis

Christopher M. Long, Timothy Smith, Todd A. Loehrl, Richard A. Komorowski, Robert J. Toohill

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Sarcoidosis is a chronic granulomatous disease of unclear etiology with a propensity to involve the lower respiratory tract, but may also involve the upper respiratory tract. Histologically, it is characterized by non-caseating granulomas of various organ systems. Although nasal and sinus involvement is uncommon, patients with sarcoidosis presenting with nasal and sinus complaints may have sinonasal sarcoidosis or simply rhinosinusitis. We reviewed the cases of six patients with pulmonary sarcoidosis who developed chronic sinonasal disease. All six patients had intranasal findings consistent with sinonasal sarcoidosis, but only four had histologic evidence of sinonasal sarcoidosis. These four patients continue to require extensive therapy including topical steroids, systemic steroids, intralesional steroid injections, and nasal irrigations. We conclude that patients with histologically proven sinonasal sarcoidosis present a significant therapeutic challenge because their symptoms and physical findings are often persistent despite aggressive medical and surgical therapy. Their recalcitrant sinonasal disease is thought to result from the destruction of cilia and mucus-producing glands by the granulomatous process.

Original languageEnglish (US)
Pages (from-to)211-215
Number of pages5
JournalAmerican Journal of Rhinology
Volume15
Issue number3
StatePublished - May 2001
Externally publishedYes

Fingerprint

Sarcoidosis
Paranasal Sinuses
Steroids
Respiratory System
Nasal Lavage
Intralesional Injections
Pulmonary Sarcoidosis
Chronic Granulomatous Disease
Cilia
Mucus
Granuloma
Chronic Disease
Therapeutics

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Long, C. M., Smith, T., Loehrl, T. A., Komorowski, R. A., & Toohill, R. J. (2001). Sinonasal disease in patients with sarcoidosis. American Journal of Rhinology, 15(3), 211-215.

Sinonasal disease in patients with sarcoidosis. / Long, Christopher M.; Smith, Timothy; Loehrl, Todd A.; Komorowski, Richard A.; Toohill, Robert J.

In: American Journal of Rhinology, Vol. 15, No. 3, 05.2001, p. 211-215.

Research output: Contribution to journalArticle

Long, CM, Smith, T, Loehrl, TA, Komorowski, RA & Toohill, RJ 2001, 'Sinonasal disease in patients with sarcoidosis', American Journal of Rhinology, vol. 15, no. 3, pp. 211-215.
Long CM, Smith T, Loehrl TA, Komorowski RA, Toohill RJ. Sinonasal disease in patients with sarcoidosis. American Journal of Rhinology. 2001 May;15(3):211-215.
Long, Christopher M. ; Smith, Timothy ; Loehrl, Todd A. ; Komorowski, Richard A. ; Toohill, Robert J. / Sinonasal disease in patients with sarcoidosis. In: American Journal of Rhinology. 2001 ; Vol. 15, No. 3. pp. 211-215.
@article{a76479e9f28f4726a3ac31485e446e64,
title = "Sinonasal disease in patients with sarcoidosis",
abstract = "Sarcoidosis is a chronic granulomatous disease of unclear etiology with a propensity to involve the lower respiratory tract, but may also involve the upper respiratory tract. Histologically, it is characterized by non-caseating granulomas of various organ systems. Although nasal and sinus involvement is uncommon, patients with sarcoidosis presenting with nasal and sinus complaints may have sinonasal sarcoidosis or simply rhinosinusitis. We reviewed the cases of six patients with pulmonary sarcoidosis who developed chronic sinonasal disease. All six patients had intranasal findings consistent with sinonasal sarcoidosis, but only four had histologic evidence of sinonasal sarcoidosis. These four patients continue to require extensive therapy including topical steroids, systemic steroids, intralesional steroid injections, and nasal irrigations. We conclude that patients with histologically proven sinonasal sarcoidosis present a significant therapeutic challenge because their symptoms and physical findings are often persistent despite aggressive medical and surgical therapy. Their recalcitrant sinonasal disease is thought to result from the destruction of cilia and mucus-producing glands by the granulomatous process.",
author = "Long, {Christopher M.} and Timothy Smith and Loehrl, {Todd A.} and Komorowski, {Richard A.} and Toohill, {Robert J.}",
year = "2001",
month = "5",
language = "English (US)",
volume = "15",
pages = "211--215",
journal = "American Journal of Rhinology and Allergy",
issn = "1945-8924",
publisher = "OceanSide Publications Inc.",
number = "3",

}

TY - JOUR

T1 - Sinonasal disease in patients with sarcoidosis

AU - Long, Christopher M.

AU - Smith, Timothy

AU - Loehrl, Todd A.

AU - Komorowski, Richard A.

AU - Toohill, Robert J.

PY - 2001/5

Y1 - 2001/5

N2 - Sarcoidosis is a chronic granulomatous disease of unclear etiology with a propensity to involve the lower respiratory tract, but may also involve the upper respiratory tract. Histologically, it is characterized by non-caseating granulomas of various organ systems. Although nasal and sinus involvement is uncommon, patients with sarcoidosis presenting with nasal and sinus complaints may have sinonasal sarcoidosis or simply rhinosinusitis. We reviewed the cases of six patients with pulmonary sarcoidosis who developed chronic sinonasal disease. All six patients had intranasal findings consistent with sinonasal sarcoidosis, but only four had histologic evidence of sinonasal sarcoidosis. These four patients continue to require extensive therapy including topical steroids, systemic steroids, intralesional steroid injections, and nasal irrigations. We conclude that patients with histologically proven sinonasal sarcoidosis present a significant therapeutic challenge because their symptoms and physical findings are often persistent despite aggressive medical and surgical therapy. Their recalcitrant sinonasal disease is thought to result from the destruction of cilia and mucus-producing glands by the granulomatous process.

AB - Sarcoidosis is a chronic granulomatous disease of unclear etiology with a propensity to involve the lower respiratory tract, but may also involve the upper respiratory tract. Histologically, it is characterized by non-caseating granulomas of various organ systems. Although nasal and sinus involvement is uncommon, patients with sarcoidosis presenting with nasal and sinus complaints may have sinonasal sarcoidosis or simply rhinosinusitis. We reviewed the cases of six patients with pulmonary sarcoidosis who developed chronic sinonasal disease. All six patients had intranasal findings consistent with sinonasal sarcoidosis, but only four had histologic evidence of sinonasal sarcoidosis. These four patients continue to require extensive therapy including topical steroids, systemic steroids, intralesional steroid injections, and nasal irrigations. We conclude that patients with histologically proven sinonasal sarcoidosis present a significant therapeutic challenge because their symptoms and physical findings are often persistent despite aggressive medical and surgical therapy. Their recalcitrant sinonasal disease is thought to result from the destruction of cilia and mucus-producing glands by the granulomatous process.

UR - http://www.scopus.com/inward/record.url?scp=0034964320&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034964320&partnerID=8YFLogxK

M3 - Article

C2 - 11453511

AN - SCOPUS:0034964320

VL - 15

SP - 211

EP - 215

JO - American Journal of Rhinology and Allergy

JF - American Journal of Rhinology and Allergy

SN - 1945-8924

IS - 3

ER -