Single-dose intravenous iron for iron deficiency: a new paradigm

Michael Auerbach, Thomas Deloughery

    Research output: Contribution to journalReview article

    25 Scopus citations

    Abstract

    Iron-deficiency anemia is the most common hematologic problem in the world. Although oral iron is often viewed as front-line therapy, extensive published evidence has accumulated that IV iron is superior, in both efficacy and safety, to oral iron in many clinical situations and should be introduced much sooner in the treatment paradigm of iron-deficient patients. In this chapter, we will review the formulations of IV iron that allow total complete replacement doses in 1 or 2 sessions including practical tips for administration. We realize safety concerns abound and therefore will analyze evidence based overstated concerns regarding serious adverse events highlighting unnecessary interventions for minor, self-limiting infusion reactions, which infrequently occur with intravenous iron administration. Recent data for the use of IV iron in a variety of clinic situations will be reviewed including women with heavy uterine bleeding, pregnancy, bariatric surgery, inflammatory bowel disease, and restless legs syndrome. Briefly discussed is the new frontier of IV iron's use in the prevention of acute (high altitude) mountain sickness. It is clear that in many clinical situations IV iron is a new and improved standard of care offering advantages over oral iron in efficacy, toxicity, and convenience to patients and health care providers.

    Original languageEnglish (US)
    Pages (from-to)57-66
    Number of pages10
    JournalHematology. American Society of Hematology. Education Program
    Volume2016
    Issue number1
    StatePublished - Dec 2 2016

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    ASJC Scopus subject areas

    • Medicine(all)
    • Hematology

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