Single Cell Spatial Biology for Precision Cancer Medicine

Andrew J. Gentles, Ajit J. Nirmal, Laura M. Heiser, Emma Lundberg, Aaron M. Newman

Research output: Contribution to journalConference articlepeer-review

Abstract

In cancer, complex ecosystems of interacting cell types play fundamental roles in tumor development, progression, and response to therapy. However, the cellular organization, community structure, and spatially defined microenvironments of human tumors remain poorly understood. With the emergence of new technologies for high-throughput spatial profiling of complex tissue specimens, it is now possible to identify clinically significant spatial features with high granularity. In this PSB workshop, we will highlight recent advances in this area and explore how single cell spatial profiling can advance precision cancer medicine.

Original languageEnglish (US)
Pages (from-to)549-553
Number of pages5
JournalPacific Symposium on Biocomputing
Issue number2023
DOIs
StatePublished - 2023
Event28th Pacific Symposium on Biocomputing, PSB 2023 - Kohala Coast, United States
Duration: Jan 3 2023Jan 7 2023

Keywords

  • artificial intelligence
  • cancer biology
  • machine learning
  • precision medicine
  • Spatial biology
  • spatial transcriptomics

ASJC Scopus subject areas

  • Medicine(all)

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