Single-Cell Proteomics Analysis of Recurrent Low-Grade Serous Ovarian Carcinoma and Associated Brain Metastases

Tanja Pejovic, Pierre Valérien Abate, Hongli Ma, Jaclyn Thiessen, Christopher L. Corless, Abigail Peterson, Hugues Allard-Chamard, Marilyne Labrie

Research output: Contribution to journalArticlepeer-review

Abstract

Between 2% and 6% of epithelial ovarian cancer (EOC) patients develop brain metastases (brain mets), which are incurable and invariably result in death. This poor outcome is associated with a lack of established guidelines for the detection and treatment of brain mets in EOC patients. In this study, we characterize an unusual case of low-grade serous ovarian carcinoma (LGSOC) that metastasized to the brain. Using a spatially oriented single-cell proteomics platform, we compared sequential biopsies of a primary tumor with a peritoneal recurrence and brain mets. We identified several targetable oncogenic pathways and immunosuppressive mechanisms that are amplified in the brain mets and could be involved in the progression of LGSOC to the brain. Furthermore, we were able to identify cell populations that are shared between the primary tumor and the brain mets, suggesting that cells that have a propensity for metastasis to the brain could be identified early during the course of disease. Taken together, our findings further a path for personalized therapeutic decisions in LGSOC.

Original languageEnglish (US)
Article number903806
JournalFrontiers in Oncology
Volume12
DOIs
StatePublished - May 25 2022

Keywords

  • brain metastases
  • cyclic immunofluorescence
  • low-grade serous ovarian cancer
  • single-cell proteomics
  • spatial analysis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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