Simultaneous depth-resolved imaging of sub-nanometer scale ossicular vibrations and morphological features of the human-cadaver middle ear with spectral-domain phase-sensitive optical coherence tomography

Hrebesh M. Subhash, Anh Nguyen-Huynh, Ruikang K. Wang, Steven Jacques, Alfred Nuttall

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We describe a novel method for the detection of the tiny motions of the middle ear (ME) ossicles and their morphological features with a spectral-domain phase sensitive optical coherence tomography (PS-OCT). Laser Doppler Vibrometry (LDV) and its variations are the most extensively used methods for studding the vibrational modes of the ME. However, most techniques are limited to single point analysis methods, and do not have the ability to provide depth resolved simultaneous imaging of multiple points on the ossicles especially with the intact eardrum. Consequently, the methods have the limited ability to provide relative vibration information at these points. In this study, we demonstrated the feasibility of using PS-OCT for simultaneous depth resolved imaging of both vibration information and morphological features in a cadaver human middle ear with high sensitivity and resolution. This technique has the potential to provide meaningful vibration of ossicles with a vibration sensitivity of ~0.5nm at 1kHz acoustic stimulation. To the best of our knowledge, this is the first demonstration of depthresolved vibration imaging of ossicles with a PS-OCT system at sub-nanometer scale.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8207
DOIs
StatePublished - 2012
EventPhotonic Therapeutics and Diagnostics VIII - San Francisco, CA, United States
Duration: Jan 21 2012Jan 24 2012

Other

OtherPhotonic Therapeutics and Diagnostics VIII
CountryUnited States
CitySan Francisco, CA
Period1/21/121/24/12

Fingerprint

middle ear
Optical tomography
Optical Coherence Tomography
Middle Ear
Vibration
Cadaver
tomography
Imaging techniques
vibration
Ear Ossicles
Vibrations (mechanical)
eardrums
Demonstrations
Acoustic Stimulation
Acoustics
Tympanic Membrane
sensitivity
stimulation
Lasers
vibration mode

Keywords

  • Biomedical optical imaging
  • Hearing research
  • Image processing
  • Optical interferometry
  • Optical vibrometry
  • Phase-sensitive optical coherence tomography
  • Spectral interferometry

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Simultaneous depth-resolved imaging of sub-nanometer scale ossicular vibrations and morphological features of the human-cadaver middle ear with spectral-domain phase-sensitive optical coherence tomography. / Subhash, Hrebesh M.; Nguyen-Huynh, Anh; Wang, Ruikang K.; Jacques, Steven; Nuttall, Alfred.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8207 2012. 82072C.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Subhash, HM, Nguyen-Huynh, A, Wang, RK, Jacques, S & Nuttall, A 2012, Simultaneous depth-resolved imaging of sub-nanometer scale ossicular vibrations and morphological features of the human-cadaver middle ear with spectral-domain phase-sensitive optical coherence tomography. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8207, 82072C, Photonic Therapeutics and Diagnostics VIII, San Francisco, CA, United States, 1/21/12. https://doi.org/10.1117/12.920839
Subhash, Hrebesh M. ; Nguyen-Huynh, Anh ; Wang, Ruikang K. ; Jacques, Steven ; Nuttall, Alfred. / Simultaneous depth-resolved imaging of sub-nanometer scale ossicular vibrations and morphological features of the human-cadaver middle ear with spectral-domain phase-sensitive optical coherence tomography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8207 2012.
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