Simultaneous acquisition of T and T2 quantification in knee cartilage: Repeatability and diurnal variation

Xiaojuan Li, Cory Wyatt, Julien Rivoire, Eric Han, Weitian Chen, Joseph Schooler, Fei Liang, Keerthi Shet, Richard Souza, Sharmila Majumdar

Research output: Contribution to journalArticlepeer-review

92 Scopus citations


Purpose To develop a robust sequence that combines T and T2 quantifications and to examine the in vivo repeatability and diurnal variation of T and T2 quantifications in knee cartilage. Materials and Methods Six healthy volunteers were scanned in the morning and afternoon on 2 days using a combined T and T 2 quantification sequence developed in this study. Repeatability of T and T2 quantification was estimated using root-mean-square coefficients-of-variation (RMS-CV). T and T2 values from morning scans were compared to those from afternoon scans using paired t-tests. Results The overall RMS-CV of in vivo T and T2 quantification was 5.3% and 5.2%, respectively. The RMS-CV of am scans was 4.2% and 5.0% while the RMS-CV of pm scans was 6.0% and 6.3% for T and T2, respectively. No significant difference was found between T or T2 values in the morning and in the afternoon. Conclusion A sequence that combines T and T2 quantification with scan time less than 10 minutes and is robust to B0 and B1 inhomogeneity was developed with excellent repeatability. For a cohort with low-level daily activity, although no significant diurnal variation of cartilage MR relaxation times was observed, the afternoon scans had inferior repeatability compared to morning scans. J. Magn. Reson. Imaging 2014;39:1287-1293. © 2013 Wiley Periodicals, Inc.

Original languageEnglish (US)
Pages (from-to)1287-1293
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Issue number5
StatePublished - May 2014
Externally publishedYes


  • cartilage degeneration
  • diurnal variation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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