Simulated shift work in rats perturbs multiscale regulation of locomotor activity

Wan Hsin Hsieh, Carolina Escobar, Tatiana Yugay, Men Tzung Lo, Benjamin Pittman-Polletta, Roberto Salgado-Delgado, Frank A.J.L. Scheer, Steven Shea, Ruud M. Buijs, Kun Hu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Motor activity possesses a multiscale regulation that is characterized by fractal activity fluctuations with similar structure across a wide range of timescales spanning minutes to hours. Fractal activity patterns are disturbed in animals after ablating the master circadian pacemaker (suprachiasmatic nucleus, SCN) and in humans with SCN dysfunction as occurs with aging and in dementia, suggesting the crucial role of the circadian system in the multiscale activity regulation.We hypothesized that the normal synchronization between behavioural cycles and the SCN-generated circadian rhythms is required for multiscale activity regulation. To test the hypothesis,we studied activity fluctuations of rats in a simulated shift work protocol that was designed to force animals to be active during the habitual resting phase of the circadian/daily cycle. We found that these animals had gradually decreased mean activity level and reduced 24-h activity rhythm amplitude, indicating disturbed circadian and behavioural cycles. Moreover, these animals had disrupted fractal activity patterns as characterized by more random activity fluctuations at multiple timescales from 4 to 12 h. Intriguingly, these activity disturbances exacerbated when the shift work schedule lasted longer and persisted even in the normal days (without forced activity) following the shift work. The disrupted circadian and fractal patterns resemble those of SCN-lesioned animals and of human patients with dementia, suggesting a detrimental impact of shift work on multiscale activity regulation.

Original languageEnglish (US)
Article number20140318
JournalJournal of the Royal Society Interface
Volume11
Issue number96
DOIs
StatePublished - Jul 6 2014

Fingerprint

Locomotion
Fractals
Suprachiasmatic Nucleus
Rats
Animals
Dementia
Pacemakers
Circadian Rhythm
Appointments and Schedules
Synchronization
Motor Activity
Aging of materials

Keywords

  • Circadian misalignment
  • Multiscale regulation
  • Shift work

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biophysics
  • Biochemistry
  • Biomaterials
  • Biomedical Engineering

Cite this

Hsieh, W. H., Escobar, C., Yugay, T., Lo, M. T., Pittman-Polletta, B., Salgado-Delgado, R., ... Hu, K. (2014). Simulated shift work in rats perturbs multiscale regulation of locomotor activity. Journal of the Royal Society Interface, 11(96), [20140318]. https://doi.org/10.1098/rsif.2014.0318

Simulated shift work in rats perturbs multiscale regulation of locomotor activity. / Hsieh, Wan Hsin; Escobar, Carolina; Yugay, Tatiana; Lo, Men Tzung; Pittman-Polletta, Benjamin; Salgado-Delgado, Roberto; Scheer, Frank A.J.L.; Shea, Steven; Buijs, Ruud M.; Hu, Kun.

In: Journal of the Royal Society Interface, Vol. 11, No. 96, 20140318, 06.07.2014.

Research output: Contribution to journalArticle

Hsieh, WH, Escobar, C, Yugay, T, Lo, MT, Pittman-Polletta, B, Salgado-Delgado, R, Scheer, FAJL, Shea, S, Buijs, RM & Hu, K 2014, 'Simulated shift work in rats perturbs multiscale regulation of locomotor activity', Journal of the Royal Society Interface, vol. 11, no. 96, 20140318. https://doi.org/10.1098/rsif.2014.0318
Hsieh WH, Escobar C, Yugay T, Lo MT, Pittman-Polletta B, Salgado-Delgado R et al. Simulated shift work in rats perturbs multiscale regulation of locomotor activity. Journal of the Royal Society Interface. 2014 Jul 6;11(96). 20140318. https://doi.org/10.1098/rsif.2014.0318
Hsieh, Wan Hsin ; Escobar, Carolina ; Yugay, Tatiana ; Lo, Men Tzung ; Pittman-Polletta, Benjamin ; Salgado-Delgado, Roberto ; Scheer, Frank A.J.L. ; Shea, Steven ; Buijs, Ruud M. ; Hu, Kun. / Simulated shift work in rats perturbs multiscale regulation of locomotor activity. In: Journal of the Royal Society Interface. 2014 ; Vol. 11, No. 96.
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