Simple numerical chromosome aberrations in well-differentiated malignant epithelial tumors

Tanja Pejovic, Sverre Heim, Charlotte Örndal, Yuesheng Jin, Nils Mandahl, Helena Willén, Felix Mitelman

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Cytogenetic analysis of four well-differentiated malignant epithelial tumors revealed primary clones with only numerical abnormalities. The karyotypes were 49,XX,+5,+5,+7, +7, -17 50,XX,+5,+5,+7,+7,-17,+r in an adenocarcinoma of the lung; 47,XX, +3 47,XX, +5 47,XX,+7 in a squamous cell carcinoma of the epiglottis; 47,XX, +5 48,XX,+5,+10 in a squamous cell carcinoma developing in an ovarian dermoid cyst; and 52,XX,+5,+7, +8,+14,+15,+21 in a seropapillary ovarian adenocarcinoma. Also, in previously published cases exclusively numerical aberrations were much more common in highly differentiated epithelial tumors ( 22 74) than in moderately to low-differentiated carcinomas ( 13 281). Our findings and the literature data thus agree with a developmental scheme in which numerical changes, possibly reflecting an early-onset genomic instability in the tumor cells, may precede massive structural anomalies in the gradual malignization of epithelial tumors.

Original languageEnglish (US)
Pages (from-to)95-101
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume49
Issue number1
DOIs
StatePublished - Oct 1 1990
Externally publishedYes

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Chromosome Aberrations
Carcinoma
Squamous Cell Carcinoma
Epiglottis
Neoplasms
Genomic Instability
Cytogenetic Analysis
Karyotype
Adenocarcinoma
Clone Cells
Ovarian Teratoma
Adenocarcinoma of lung

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Simple numerical chromosome aberrations in well-differentiated malignant epithelial tumors. / Pejovic, Tanja; Heim, Sverre; Örndal, Charlotte; Jin, Yuesheng; Mandahl, Nils; Willén, Helena; Mitelman, Felix.

In: Cancer Genetics and Cytogenetics, Vol. 49, No. 1, 01.10.1990, p. 95-101.

Research output: Contribution to journalArticle

Pejovic, Tanja ; Heim, Sverre ; Örndal, Charlotte ; Jin, Yuesheng ; Mandahl, Nils ; Willén, Helena ; Mitelman, Felix. / Simple numerical chromosome aberrations in well-differentiated malignant epithelial tumors. In: Cancer Genetics and Cytogenetics. 1990 ; Vol. 49, No. 1. pp. 95-101.
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AU - Willén, Helena

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