TY - JOUR
T1 - Simple numerical chromosome aberrations in well-differentiated malignant epithelial tumors
AU - Pejovic, Tanja
AU - Heim, Sverre
AU - Örndal, Charlotte
AU - Jin, Yuesheng
AU - Mandahl, Nils
AU - Willén, Helena
AU - Mitelman, Felix
PY - 1990/10/1
Y1 - 1990/10/1
N2 - Cytogenetic analysis of four well-differentiated malignant epithelial tumors revealed primary clones with only numerical abnormalities. The karyotypes were 49,XX,+5,+5,+7, +7, -17 50,XX,+5,+5,+7,+7,-17,+r in an adenocarcinoma of the lung; 47,XX, +3 47,XX, +5 47,XX,+7 in a squamous cell carcinoma of the epiglottis; 47,XX, +5 48,XX,+5,+10 in a squamous cell carcinoma developing in an ovarian dermoid cyst; and 52,XX,+5,+7, +8,+14,+15,+21 in a seropapillary ovarian adenocarcinoma. Also, in previously published cases exclusively numerical aberrations were much more common in highly differentiated epithelial tumors ( 22 74) than in moderately to low-differentiated carcinomas ( 13 281). Our findings and the literature data thus agree with a developmental scheme in which numerical changes, possibly reflecting an early-onset genomic instability in the tumor cells, may precede massive structural anomalies in the gradual malignization of epithelial tumors.
AB - Cytogenetic analysis of four well-differentiated malignant epithelial tumors revealed primary clones with only numerical abnormalities. The karyotypes were 49,XX,+5,+5,+7, +7, -17 50,XX,+5,+5,+7,+7,-17,+r in an adenocarcinoma of the lung; 47,XX, +3 47,XX, +5 47,XX,+7 in a squamous cell carcinoma of the epiglottis; 47,XX, +5 48,XX,+5,+10 in a squamous cell carcinoma developing in an ovarian dermoid cyst; and 52,XX,+5,+7, +8,+14,+15,+21 in a seropapillary ovarian adenocarcinoma. Also, in previously published cases exclusively numerical aberrations were much more common in highly differentiated epithelial tumors ( 22 74) than in moderately to low-differentiated carcinomas ( 13 281). Our findings and the literature data thus agree with a developmental scheme in which numerical changes, possibly reflecting an early-onset genomic instability in the tumor cells, may precede massive structural anomalies in the gradual malignization of epithelial tumors.
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U2 - 10.1016/0165-4608(90)90168-A
DO - 10.1016/0165-4608(90)90168-A
M3 - Article
C2 - 2397477
AN - SCOPUS:0025002235
SN - 0165-4608
VL - 49
SP - 95
EP - 101
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -