Simple numerical chromosome aberrations in well-differentiated malignant epithelial tumors

Tanja Pejovic, Sverre Heim, Charlotte Örndal, Yuesheng Jin, Nils Mandahl, Helena Willén, Felix Mitelman

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Cytogenetic analysis of four well-differentiated malignant epithelial tumors revealed primary clones with only numerical abnormalities. The karyotypes were 49,XX,+5,+5,+7, +7, -17 50,XX,+5,+5,+7,+7,-17,+r in an adenocarcinoma of the lung; 47,XX, +3 47,XX, +5 47,XX,+7 in a squamous cell carcinoma of the epiglottis; 47,XX, +5 48,XX,+5,+10 in a squamous cell carcinoma developing in an ovarian dermoid cyst; and 52,XX,+5,+7, +8,+14,+15,+21 in a seropapillary ovarian adenocarcinoma. Also, in previously published cases exclusively numerical aberrations were much more common in highly differentiated epithelial tumors ( 22 74) than in moderately to low-differentiated carcinomas ( 13 281). Our findings and the literature data thus agree with a developmental scheme in which numerical changes, possibly reflecting an early-onset genomic instability in the tumor cells, may precede massive structural anomalies in the gradual malignization of epithelial tumors.

Original languageEnglish (US)
Pages (from-to)95-101
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume49
Issue number1
DOIs
StatePublished - Oct 1 1990
Externally publishedYes

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ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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