Simple induction and assessment of barbiturate physical dependence in the rat

Richard Letz, J. K. Belknap

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Physical dependence to phenobarbital via an oral ingestion method was demonstrated in rats. Also, the utility of air-puff-elicited startle for assessing both intoxication and withdrawal effects was shown. Avoidance of phenobarbital-adulterated food was enhanced as a result of prior exposure to chronic phenobarbital intoxication and subsequent withdrawal.

Original languageEnglish (US)
Pages (from-to)249-252
Number of pages4
JournalPhysiological Psychology
Volume3
Issue number3
DOIs
StatePublished - Sep 1975

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

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