Similar chemotactic factor for monocytes predominates in different animal models of uveitis

James T. Rosenbaum, Brian W.P. Seymour, Wilfred Raymond, Lisa Langlois, Martin Wu, Larry David

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Anterior uveitis or iritis occurs in a variety of systemic diseases including sarcoid, Behcet's, and spondyloarthritis. Iritis is, therefore, presumed to result from a variety of pathogenetic mechanisms. We hypothesized that unique chemotactic factors should be associated with different etiologies for inflammation. We have tested this hypothesis using rabbit models of anterior uveitis. We have found that aqueous humor generally contained chemotactic activity for monocytes 24 h after an intravitreal injection of endotoxin, killed mycobacteria, or human serum albumin (in a rabbit previously immunized against human serum albumin). Anterior chamber paracentesis resulted in aqueous humor with a high protein content. However, in contrast to the other models of inflammation, paracentesis did not result in a cellular infiltrate in the anterior chamber, and aqueous humor after paracentesis was not chemotactic. For either immunologically mediated inflammation or for inflammation resulting from injection of a killed bacterial product, chemotactic activity could be digested by papain or trypsin and tended to coelute with albumin on either gel filtration or ion-exchange chromatography. These observations suggest that a similar chemotactic factor for monocytes appears to be associated with ocular inflammation that follows either an immune response or injection of a killed bacterial product.

Original languageEnglish (US)
Pages (from-to)191-201
Number of pages11
JournalInflammation
Volume12
Issue number3
DOIs
StatePublished - Jun 1 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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