Simian immunodeficiency virus-specific CD8+ T cells recognize Vpr- and Rev-derived epitopes early after infection

Jonah Sacha, Matthew B. Buechler, Laura P. Newman, Jason Reed, Lyle T. Wallace, John T. Loffredo, Nancy A. Wilson, David I. Watkins

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The kinetics of CD8+ T cell epitope presentation contribute to the antiviral efficacy of these cells yet remain poorly defined. Here, we demonstrate presentation of virion-derived Vpr peptide epitopes early after viral penetration and prior to presentation of Vif-derived epitopes, which required de novo Vif synthesis. Two Rev epitopes exhibited differential presentation kinetics, with one Rev epitope presented within 1 h of infection. We also demonstrate that cytolytic activity mirrors the recognition kinetics of infected cells. These studies show for the first time that Vpr- and Rev-specific CD8+ T cells recognize and kill simian immunodeficiency virus (SIV)-infected CD4+ T cells early after SIV infection.

Original languageEnglish (US)
Pages (from-to)10907-10912
Number of pages6
JournalJournal of Virology
Volume84
Issue number20
DOIs
StatePublished - Oct 2010
Externally publishedYes

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Simian immunodeficiency virus
Simian Immunodeficiency Virus
epitopes
Epitopes
T-lymphocytes
T-Lymphocytes
Infection
infection
kinetics
T-Lymphocyte Epitopes
Virus Diseases
Virion
Antiviral Agents
virion
Peptides
peptides
cells
synthesis

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Sacha, J., Buechler, M. B., Newman, L. P., Reed, J., Wallace, L. T., Loffredo, J. T., ... Watkins, D. I. (2010). Simian immunodeficiency virus-specific CD8+ T cells recognize Vpr- and Rev-derived epitopes early after infection. Journal of Virology, 84(20), 10907-10912. https://doi.org/10.1128/JVI.01357-10

Simian immunodeficiency virus-specific CD8+ T cells recognize Vpr- and Rev-derived epitopes early after infection. / Sacha, Jonah; Buechler, Matthew B.; Newman, Laura P.; Reed, Jason; Wallace, Lyle T.; Loffredo, John T.; Wilson, Nancy A.; Watkins, David I.

In: Journal of Virology, Vol. 84, No. 20, 10.2010, p. 10907-10912.

Research output: Contribution to journalArticle

Sacha, J, Buechler, MB, Newman, LP, Reed, J, Wallace, LT, Loffredo, JT, Wilson, NA & Watkins, DI 2010, 'Simian immunodeficiency virus-specific CD8+ T cells recognize Vpr- and Rev-derived epitopes early after infection', Journal of Virology, vol. 84, no. 20, pp. 10907-10912. https://doi.org/10.1128/JVI.01357-10
Sacha, Jonah ; Buechler, Matthew B. ; Newman, Laura P. ; Reed, Jason ; Wallace, Lyle T. ; Loffredo, John T. ; Wilson, Nancy A. ; Watkins, David I. / Simian immunodeficiency virus-specific CD8+ T cells recognize Vpr- and Rev-derived epitopes early after infection. In: Journal of Virology. 2010 ; Vol. 84, No. 20. pp. 10907-10912.
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