Simian immunodeficiency virus-induced intestinal cell apoptosis is the underlying mechanism of the regenerative enteropathy of early infection

Qingsheng Li, Jacob Estes, Lijie Duan, Jose Jessurun, Stefan Pambuccian, Colleen Forster, Stephen Wietgrefe, Mary Zupancic, Timothy Schacker, Cavan Reilly, John V. Carlis, Ashley T. Haase

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

The enteropathic manifestations of the human immunodeficiency virus (HIV) and the simian immunodeficiency virus (SIV) in late infection are usually due to infection by other microbes, but in early infection the viruses themselves cause an enteropathy by heretofore undetermined mechanisms. Here we report that SIV induces massive apoptosis of intestinal epithelial cells lining the small and large bowel, thus identifying apoptosis as the driving force behind the regenerative pathology of early infection. We found that apoptosis of gut epithelium paralleled the previously documented apoptosis and massive depletion of CD4 T cells in gut lamina propria, triggered by established mechanisms of gut epithelial cell apoptosis and, at peak, possibly by virus interactions with GPR15/Bob, an intestinal epithelial cell-associated alternative coreceptor for SIV and HIV-1. Apoptosis in early SIV infection is thus the common theme of the pathological processes that quickly afflict the innate as well as adaptive arms of the gut immune system.

Original languageEnglish (US)
Pages (from-to)420-429
Number of pages10
JournalJournal of Infectious Diseases
Volume197
Issue number3
DOIs
StatePublished - Feb 1 2008
Externally publishedYes

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Simian Immunodeficiency Virus
Apoptosis
Infection
Epithelial Cells
Virus Diseases
Pathologic Processes
HIV-1
Immune System
Mucous Membrane
Epithelium
HIV
Pathology
Viruses
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Simian immunodeficiency virus-induced intestinal cell apoptosis is the underlying mechanism of the regenerative enteropathy of early infection. / Li, Qingsheng; Estes, Jacob; Duan, Lijie; Jessurun, Jose; Pambuccian, Stefan; Forster, Colleen; Wietgrefe, Stephen; Zupancic, Mary; Schacker, Timothy; Reilly, Cavan; Carlis, John V.; Haase, Ashley T.

In: Journal of Infectious Diseases, Vol. 197, No. 3, 01.02.2008, p. 420-429.

Research output: Contribution to journalArticle

Li, Q, Estes, J, Duan, L, Jessurun, J, Pambuccian, S, Forster, C, Wietgrefe, S, Zupancic, M, Schacker, T, Reilly, C, Carlis, JV & Haase, AT 2008, 'Simian immunodeficiency virus-induced intestinal cell apoptosis is the underlying mechanism of the regenerative enteropathy of early infection', Journal of Infectious Diseases, vol. 197, no. 3, pp. 420-429. https://doi.org/10.1086/525046
Li, Qingsheng ; Estes, Jacob ; Duan, Lijie ; Jessurun, Jose ; Pambuccian, Stefan ; Forster, Colleen ; Wietgrefe, Stephen ; Zupancic, Mary ; Schacker, Timothy ; Reilly, Cavan ; Carlis, John V. ; Haase, Ashley T. / Simian immunodeficiency virus-induced intestinal cell apoptosis is the underlying mechanism of the regenerative enteropathy of early infection. In: Journal of Infectious Diseases. 2008 ; Vol. 197, No. 3. pp. 420-429.
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