Silicate Nephrolithiasis After Ingestion of Supplements Containing Silica Dioxide

Jennifer E. Flythe, Jose Rueda, Michael Riscoe, Suzanne Watnick

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Silicate calculi are common in some mammals, such as dogs and sheep, but extremely rare in humans. We report a case of silicate calculi in a woman using oral over-the-counter Uncaria tomentosa, Digestive Advantage and FlexProtex supplements. All 3 contained the excipient silica dioxide. Stone analysis showed composition of 100% silicate. The nephrolithiasis promptly abated after discontinuation of the products containing silica, then returned when the patient restarted her supplements. This case emphasizes the importance of stone analysis when obvious causes of nephrolithiasis are unclear and highlights the concerns of using over-the-counter supplements without substantial oversight.

Original languageEnglish (US)
Pages (from-to)127-130
Number of pages4
JournalAmerican Journal of Kidney Diseases
Volume54
Issue number1
DOIs
StatePublished - Jul 2009

Fingerprint

Silicates
Nephrolithiasis
Silicon Dioxide
Eating
Calculi
Cat's Claw
Excipients
Mammals
Sheep
Dogs

Keywords

  • nephrolithiasis
  • over-the-counter supplements
  • silica
  • Silicate

ASJC Scopus subject areas

  • Nephrology

Cite this

Silicate Nephrolithiasis After Ingestion of Supplements Containing Silica Dioxide. / Flythe, Jennifer E.; Rueda, Jose; Riscoe, Michael; Watnick, Suzanne.

In: American Journal of Kidney Diseases, Vol. 54, No. 1, 07.2009, p. 127-130.

Research output: Contribution to journalArticle

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