Silent renal involvement in systemic lupus erythematosus.

W. M. Bennett, E. J. Bardana, D. C. Houghton, B. Pirofsky, G. D. Striker

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

20 patients with active SLE without clinical evidence of renal involvement underwent percutaneous renal biopsy. 12 had varying proliferative changes on light microscopy. Of 19 ultrastructural examinations performed only 3 had no electron-dense deposits. Serum C3 and C4 levels were 63 +/- 8 and 8 +/- 2 mg% in patients with subendothelial deposits, compared to 142 +/- 27 and 27 +/- 6 mg%, respectively, in patients without deposits (p less than 0.01). All patients with diffuse proliferative changes had subendothelial deposits; however, one with normal light microscopy and another with focal proliferation also had them. It is concluded that no variant of lupus nephropathy can be excluded on clinical grounds alone.

Original languageEnglish (US)
Pages (from-to)420-428
Number of pages9
JournalInternational Archives of Allergy and Applied Immunology
Volume55
Issue number1-6
DOIs
StatePublished - 1977

ASJC Scopus subject areas

  • Immunology and Allergy

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