Significance of Mechanical Alterations in Single Ventricle Patients on Twisting and Circumferential Strain as Determined by Analysis of Strain from Gradient Cine Magnetic Resonance Imaging Sequences

Uyen T. Truong, Xiaokui Li, Craig Broberg, Helene Houle, Michael Schaal, Muhammad Ashraf, Philip Kilner, Florence H. Sheehan, Craig A. Sable, Shuping Ge, David Sahn

Research output: Contribution to journalArticle

24 Scopus citations


Preliminary speckle-tracking echocardiographic studies show that patients with single ventricles (SVs) have significantly decreased twisting and dyssynchrony of twisting. This could be related to abnormal cardiac looping, which leads to hearts that lack helical fiber patterns. The aim of this study was to analyze gradient cine magnetic resonance imaging (MRI) using Velocity Vector Imaging to assess cardiac mechanics. Subjects were 38 patients (aged 8 to 37 years) with SVs of left ventricular (n = 30) and indeterminate (n = 8) type who underwent cardiac MRI. Controls were 14 normal children and adults. Gradient cine MRI sequences close to the apex were subjected to a Velocity Vector Imaging analysis program adapted for MRI. In the control group, mean circumferential strain was -18.02 ± 7.31%, mean dispersion of peak circumferential strain was 44.23 ± 37.14 ms, and average rotation was -7.7 ± 1.38°. The rotation values were negative, or counterclockwise. In patients with SVs, mean circumferential strain was -8.87 ± 7.30%, mean dispersion of peak circumferential strain was 181.55 ± 76.07 ms, and average rotation was -2.6 ± 1.24° (p

Original languageEnglish (US)
Pages (from-to)1465-1469
Number of pages5
JournalAmerican Journal of Cardiology
Issue number10
Publication statusPublished - May 15 2010


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this