Signals from the X: Signal transduction and X-linked mental retardation

Anthony Barnes, Sharon L. Milgram

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The dramatic increase in genomic information is allowing the rapid identification of genes that are altered in mental retardation (MR). It is necessary to place their resulting gene products in their cellular context to understand how they may have contributed to a patient's cognitive deficits. This review will consider signaling molecules that have been implicated in X-linked MR and the known pathways by which these proteins covey information will be delineated. The proteins discussed include four distinct classes: transmembrane receptors, guanine nucleotide related proteins, kinases, and translational regulators.

Original languageEnglish (US)
Pages (from-to)397-406
Number of pages10
JournalInternational Journal of Developmental Neuroscience
Volume20
Issue number3-5
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

X-Linked Mental Retardation
Signal Transduction
Guanine Nucleotides
Intellectual Disability
Protein Kinases
Genes
Proteins

Keywords

  • CREB-binding protein (CBP)
  • Cyclic AMP response element binding protein (CREB)
  • Mental retardation (MR)

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Signals from the X : Signal transduction and X-linked mental retardation. / Barnes, Anthony; Milgram, Sharon L.

In: International Journal of Developmental Neuroscience, Vol. 20, No. 3-5, 2002, p. 397-406.

Research output: Contribution to journalArticle

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