Signals from the X: Signal transduction and X-linked mental retardation

Anthony P. Barnes, Sharon L. Milgram

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The dramatic increase in genomic information is allowing the rapid identification of genes that are altered in mental retardation (MR). It is necessary to place their resulting gene products in their cellular context to understand how they may have contributed to a patient's cognitive deficits. This review will consider signaling molecules that have been implicated in X-linked MR and the known pathways by which these proteins covey information will be delineated. The proteins discussed include four distinct classes: transmembrane receptors, guanine nucleotide related proteins, kinases, and translational regulators.

Original languageEnglish (US)
Pages (from-to)397-406
Number of pages10
JournalInternational Journal of Developmental Neuroscience
Issue number3-5
StatePublished - 2002
Externally publishedYes


  • CREB-binding protein (CBP)
  • Cyclic AMP response element binding protein (CREB)
  • Mental retardation (MR)

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology


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