Signaling pathways for PC12 cell differentiation

Making the right connections

D. Vaudry, Philip Stork, P. Lazarovici, L. E. Eiden

Research output: Contribution to journalArticle

626 Citations (Scopus)

Abstract

A key issue in signal transduction is how signaling pathways common to many systems-so-called canonical signaling cassettes - integrate signals from molecules having a wide spectrum of activities, such as hormones and neurotrophins, to deliver distinct biological outcomes. The neuroendocrine cell line PC12, derived from rat pheochromocytoma, provides an example of how one canonical signaling cassette - the Raf → mitogen-activated protein kinase kinase (MEK) → extracellular signal-regulated kinase (ERK) pathway - can promote distinct outcomes, which in this case include neuritogenesis, gene induction, and proliferation. Two growth hormones, epidermal growth factor (EGF) and nerve growth factor (NGF), use the same pathway to cause PC12 proliferation and differentiation, respectively. In addition, pituitary adenylate cyclase-activating polypeptide (PACAP), a neurotransmitter that also causes differentiation, uses the same canonical cassette as NGF but in a different way. The Connections Map for PC12 Cell Differentiation brings into focus the complex array of specific cellular responses that rely on canonical signal transduction systems.

Original languageEnglish (US)
Pages (from-to)1648-1649
Number of pages2
JournalScience
Volume296
Issue number5573
DOIs
StatePublished - May 31 2002
Externally publishedYes

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PC12 Cells
Mitogen-Activated Protein Kinase Kinases
Nerve Growth Factor
Cell Differentiation
Signal Transduction
Pituitary Adenylate Cyclase-Activating Polypeptide
Neuroendocrine Cells
Extracellular Signal-Regulated MAP Kinases
Nerve Growth Factors
Pheochromocytoma
Epidermal Growth Factor
Growth Hormone
Neurotransmitter Agents
Hormones
Cell Line
Genes

ASJC Scopus subject areas

  • General

Cite this

Signaling pathways for PC12 cell differentiation : Making the right connections. / Vaudry, D.; Stork, Philip; Lazarovici, P.; Eiden, L. E.

In: Science, Vol. 296, No. 5573, 31.05.2002, p. 1648-1649.

Research output: Contribution to journalArticle

Vaudry, D. ; Stork, Philip ; Lazarovici, P. ; Eiden, L. E. / Signaling pathways for PC12 cell differentiation : Making the right connections. In: Science. 2002 ; Vol. 296, No. 5573. pp. 1648-1649.
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