Signaling networks in hepatic oval cell activation

Research output: Contribution to journalReview article

40 Scopus citations

Abstract

Oval cells are hypothesized to be the progeny of intrahepatic stem cells, also referred to as adult liver stem cells. The mechanisms by which these cells are activated to proliferate and differentiate during liver regeneration is important for the development of new therapies to treat liver disease. Oval cell activation is the first step in progenitor-dependent liver regeneration in response to certain types of injury. This review describes what is currently known about the factors involved in oval cell activation, proliferation, migration, and differentiation.

Original languageEnglish (US)
Pages (from-to)90-102
Number of pages13
JournalStem Cell Research
Volume1
Issue number2
DOIs
StatePublished - Nov 1 2008

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Signaling networks in hepatic oval cell activation'. Together they form a unique fingerprint.

  • Cite this