Signaling networks in hepatic oval cell activation

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Oval cells are hypothesized to be the progeny of intrahepatic stem cells, also referred to as adult liver stem cells. The mechanisms by which these cells are activated to proliferate and differentiate during liver regeneration is important for the development of new therapies to treat liver disease. Oval cell activation is the first step in progenitor-dependent liver regeneration in response to certain types of injury. This review describes what is currently known about the factors involved in oval cell activation, proliferation, migration, and differentiation.

Original languageEnglish (US)
Pages (from-to)90-102
Number of pages13
JournalStem Cell Research
Volume1
Issue number2
DOIs
StatePublished - Nov 2008

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Hepatocytes
Liver Regeneration
Adult Stem Cells
Liver Diseases
Stem Cells
Cell Proliferation
Liver
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Medicine(all)

Cite this

Signaling networks in hepatic oval cell activation. / Erker, Laura; Grompe, Markus.

In: Stem Cell Research, Vol. 1, No. 2, 11.2008, p. 90-102.

Research output: Contribution to journalArticle

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