Signaling mechanisms regulating Wallerian degeneration

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

Wallerian degeneration (WD) occurs after an axon is cut or crushed and entails the disintegration and clearance of the severed axon distal to the injury site. WD was initially thought to result from the passive wasting away of the distal axonal fragment, presumably because it lacked a nutrient supply from the cell body. The discovery of the slow Wallerian degeneration (Wlds) mutant mouse, in which distal severed axons survive intact for weeks rather than only one to two days, radically changed our thoughts on the autonomy of axon survival. Wlds taught us that under some conditions the axonal compartment can survive for weeks after axotomy without a cell body. The phenotypic and molecular characterization of WldS and current models for WldS molecular function are reviewed herein-the mechanism(s) by which WldS spares severed axons remains unresolved. However, recent studies inspired by Wlds have led to the identification of the first 'axon death' signaling molecules whose endogenous activities promote axon destruction during WD.

Original languageEnglish (US)
Pages (from-to)224-231
Number of pages8
JournalCurrent Opinion in Neurobiology
Volume27
DOIs
StatePublished - 2014
Externally publishedYes

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Wallerian Degeneration
Axons
Axotomy
Molecular Models
Food
Wounds and Injuries

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Signaling mechanisms regulating Wallerian degeneration. / Freeman, Marc.

In: Current Opinion in Neurobiology, Vol. 27, 2014, p. 224-231.

Research output: Contribution to journalReview article

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