Signaling at the Golgi

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

The protein processing and trafficking function of the Golgi is intimately linked to multiple intracellular signaling pathways. Assembly of Golgi trafficking structures and lipid sorting at the Golgi complex is controlled and coordinated by specific phosphoinositide kinases and phosphatases. The intra-Golgi transport machinery is also regulated by kinases belonging to several functionally distinct families, for example, MAP kinase signaling is required for mitotic disassembly of the Golgi. However, the Golgi plays an additional, prominent role in compartmentalizing other signaling cascades that originate at the plasma membrane or at other organelles. This article summarizes recent advances in our understanding of the signaling network that converges at the Golgi.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalCold Spring Harbor Perspectives in Biology
Volume3
Issue number5
DOIs
StatePublished - May 2011

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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