Abstract
An understanding of how an extracellular stimulus causes changes in cell growth is emerging from the study of four signal transduction pathways in Saccharomyces cerevisiae: the pheromone-response, pseudohyphal differentiation, osmolarity-response, and protein kinase C activated pathways. Each of these pathways contains at its core a distinct mitogen-activated protein kinase cascade. Biochemical and molecular studies have determined the functional order of the kinases in the pheromone-response pathway and have suggested that they are organized into a complex by a protein scaffold. The cell surface sensor system for the osmolarity-response pathway has been identified. It shows striking similarity to bacterial two-component sensor-responder systems. Finally, components that integrate information from these pathways and communicate it to cell growth regulators have been revealed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 31-37 |
| Number of pages | 7 |
| Journal | Current Opinion in Genetics and Development |
| Volume | 5 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1995 |
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ASJC Scopus subject areas
- Developmental Biology
- Genetics
Cite this
Signal transduction and growth control in yeast. / Schultz, Janet; Ferguson, Betsy; Sprague, George F.
In: Current Opinion in Genetics and Development, Vol. 5, No. 1, 1995, p. 31-37.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Signal transduction and growth control in yeast
AU - Schultz, Janet
AU - Ferguson, Betsy
AU - Sprague, George F.
PY - 1995
Y1 - 1995
N2 - An understanding of how an extracellular stimulus causes changes in cell growth is emerging from the study of four signal transduction pathways in Saccharomyces cerevisiae: the pheromone-response, pseudohyphal differentiation, osmolarity-response, and protein kinase C activated pathways. Each of these pathways contains at its core a distinct mitogen-activated protein kinase cascade. Biochemical and molecular studies have determined the functional order of the kinases in the pheromone-response pathway and have suggested that they are organized into a complex by a protein scaffold. The cell surface sensor system for the osmolarity-response pathway has been identified. It shows striking similarity to bacterial two-component sensor-responder systems. Finally, components that integrate information from these pathways and communicate it to cell growth regulators have been revealed.
AB - An understanding of how an extracellular stimulus causes changes in cell growth is emerging from the study of four signal transduction pathways in Saccharomyces cerevisiae: the pheromone-response, pseudohyphal differentiation, osmolarity-response, and protein kinase C activated pathways. Each of these pathways contains at its core a distinct mitogen-activated protein kinase cascade. Biochemical and molecular studies have determined the functional order of the kinases in the pheromone-response pathway and have suggested that they are organized into a complex by a protein scaffold. The cell surface sensor system for the osmolarity-response pathway has been identified. It shows striking similarity to bacterial two-component sensor-responder systems. Finally, components that integrate information from these pathways and communicate it to cell growth regulators have been revealed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028912159&partnerID=8YFLogxK
U2 - 10.1016/S0959-437X(95)90050-0
DO - 10.1016/S0959-437X(95)90050-0
M3 - Article
C2 - 7749322
AN - SCOPUS:0028912159
VL - 5
SP - 31
EP - 37
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
SN - 0959-437X
IS - 1
ER -