TY - JOUR
T1 - Signal transduction and growth control in yeast
AU - Schultz, Janet
AU - Ferguson, Betsy
AU - Sprague, George F.
PY - 1995/2
Y1 - 1995/2
N2 - An understanding of how an extracellular stimulus causes changes in cell growth is emerging from the study of four signal transduction pathways in Saccharomyces cerevisiae: the pheromone-response, pseudohyphal differentiation, osmolarity-response, and protein kinase C activated pathways. Each of these pathways contains at its core a distinct mitogen-activated protein kinase cascade. Biochemical and molecular studies have determined the functional order of the kinases in the pheromone-response pathway and have suggested that they are organized into a complex by a protein scaffold. The cell surface sensor system for the osmolarity-response pathway has been identified. It shows striking similarity to bacterial two-component sensor-responder systems. Finally, components that integrate information from these pathways and communicate it to cell growth regulators have been revealed.
AB - An understanding of how an extracellular stimulus causes changes in cell growth is emerging from the study of four signal transduction pathways in Saccharomyces cerevisiae: the pheromone-response, pseudohyphal differentiation, osmolarity-response, and protein kinase C activated pathways. Each of these pathways contains at its core a distinct mitogen-activated protein kinase cascade. Biochemical and molecular studies have determined the functional order of the kinases in the pheromone-response pathway and have suggested that they are organized into a complex by a protein scaffold. The cell surface sensor system for the osmolarity-response pathway has been identified. It shows striking similarity to bacterial two-component sensor-responder systems. Finally, components that integrate information from these pathways and communicate it to cell growth regulators have been revealed.
UR - http://www.scopus.com/inward/record.url?scp=0028912159&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028912159&partnerID=8YFLogxK
U2 - 10.1016/S0959-437X(95)90050-0
DO - 10.1016/S0959-437X(95)90050-0
M3 - Article
C2 - 7749322
AN - SCOPUS:0028912159
VL - 5
SP - 31
EP - 37
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
SN - 0959-437X
IS - 1
ER -