Sialidases on mammalian sperm mediate deciduous sialylation during capacitation

Fang Ma, Diana Wu, Liwen Deng, Patrick Secrest, June Zhao, Nissi Varki, Steven Lindheim, Pascal Gagneux

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: Mammalian sperm lose sialic acids during capacitation through unknown mechanisms. Results: Sialidases Neu1 and Neu3 are present on sperm. Their activity is required for capacitation and zona pellucida binding. Conclusion: Sperm sialidases modulate sperm surface sialic acids en route to fertilization. Significance: Understanding the mechanism of deciduous sialylation in sperm provides novel insights into sperm function and glycan-mediated fertility.

Original languageEnglish (US)
Pages (from-to)38073-38079
Number of pages7
JournalJournal of Biological Chemistry
Volume287
Issue number45
DOIs
StatePublished - Nov 2 2012
Externally publishedYes

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Sialic Acids
Spermatozoa
Polysaccharides
Zona Pellucida
Fertilization
Fertility

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Sialidases on mammalian sperm mediate deciduous sialylation during capacitation. / Ma, Fang; Wu, Diana; Deng, Liwen; Secrest, Patrick; Zhao, June; Varki, Nissi; Lindheim, Steven; Gagneux, Pascal.

In: Journal of Biological Chemistry, Vol. 287, No. 45, 02.11.2012, p. 38073-38079.

Research output: Contribution to journalArticle

Ma, F, Wu, D, Deng, L, Secrest, P, Zhao, J, Varki, N, Lindheim, S & Gagneux, P 2012, 'Sialidases on mammalian sperm mediate deciduous sialylation during capacitation', Journal of Biological Chemistry, vol. 287, no. 45, pp. 38073-38079. https://doi.org/10.1074/jbc.M112.380584
Ma, Fang ; Wu, Diana ; Deng, Liwen ; Secrest, Patrick ; Zhao, June ; Varki, Nissi ; Lindheim, Steven ; Gagneux, Pascal. / Sialidases on mammalian sperm mediate deciduous sialylation during capacitation. In: Journal of Biological Chemistry. 2012 ; Vol. 287, No. 45. pp. 38073-38079.
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