Sialidases on mammalian sperm mediate deciduous sialylation during capacitation

Fang Ma; Diana Wu; Liwen Deng; Patrick Secrest; June Zhao; Nissi Varki; Steven Lindheim; Pascal Gagneux

doi:10.1074/jbc.M112.380584

Sialidases on mammalian sperm mediate deciduous sialylation during capacitation

Fang Ma, Diana Wu, Liwen Deng, Patrick Secrest, June Zhao, Nissi Varki, Steven Lindheim, Pascal Gagneux

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Background: Mammalian sperm lose sialic acids during capacitation through unknown mechanisms. Results: Sialidases Neu1 and Neu3 are present on sperm. Their activity is required for capacitation and zona pellucida binding. Conclusion: Sperm sialidases modulate sperm surface sialic acids en route to fertilization. Significance: Understanding the mechanism of deciduous sialylation in sperm provides novel insights into sperm function and glycan-mediated fertility.

Original language	English (US)
Pages (from-to)	38073-38079
Number of pages	7
Journal	Journal of Biological Chemistry
Volume	287
Issue number	45
DOIs	https://doi.org/10.1074/jbc.M112.380584
State	Published - Nov 2 2012
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Sialidases on mammalian sperm mediate deciduous sialylation during capacitation",

abstract = "Background: Mammalian sperm lose sialic acids during capacitation through unknown mechanisms. Results: Sialidases Neu1 and Neu3 are present on sperm. Their activity is required for capacitation and zona pellucida binding. Conclusion: Sperm sialidases modulate sperm surface sialic acids en route to fertilization. Significance: Understanding the mechanism of deciduous sialylation in sperm provides novel insights into sperm function and glycan-mediated fertility.",

author = "Fang Ma and Diana Wu and Liwen Deng and Patrick Secrest and June Zhao and Nissi Varki and Steven Lindheim and Pascal Gagneux",

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T1 - Sialidases on mammalian sperm mediate deciduous sialylation during capacitation

AU - Ma, Fang

AU - Wu, Diana

AU - Deng, Liwen

AU - Secrest, Patrick

AU - Zhao, June

AU - Varki, Nissi

AU - Lindheim, Steven

AU - Gagneux, Pascal

PY - 2012/11/2

Y1 - 2012/11/2

N2 - Background: Mammalian sperm lose sialic acids during capacitation through unknown mechanisms. Results: Sialidases Neu1 and Neu3 are present on sperm. Their activity is required for capacitation and zona pellucida binding. Conclusion: Sperm sialidases modulate sperm surface sialic acids en route to fertilization. Significance: Understanding the mechanism of deciduous sialylation in sperm provides novel insights into sperm function and glycan-mediated fertility.

AB - Background: Mammalian sperm lose sialic acids during capacitation through unknown mechanisms. Results: Sialidases Neu1 and Neu3 are present on sperm. Their activity is required for capacitation and zona pellucida binding. Conclusion: Sperm sialidases modulate sperm surface sialic acids en route to fertilization. Significance: Understanding the mechanism of deciduous sialylation in sperm provides novel insights into sperm function and glycan-mediated fertility.

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JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

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Sialidases on mammalian sperm mediate deciduous sialylation during capacitation

Abstract

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