Sialidases on mammalian sperm mediate deciduous sialylation during capacitation

Fang Ma, Diana Wu, Liwen Deng, Patrick Secrest, June Zhao, Nissi Varki, Steven Lindheim, Pascal Gagneux

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Background: Mammalian sperm lose sialic acids during capacitation through unknown mechanisms. Results: Sialidases Neu1 and Neu3 are present on sperm. Their activity is required for capacitation and zona pellucida binding. Conclusion: Sperm sialidases modulate sperm surface sialic acids en route to fertilization. Significance: Understanding the mechanism of deciduous sialylation in sperm provides novel insights into sperm function and glycan-mediated fertility.

Original languageEnglish (US)
Pages (from-to)38073-38079
Number of pages7
JournalJournal of Biological Chemistry
Volume287
Issue number45
DOIs
StatePublished - Nov 2 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Ma, F., Wu, D., Deng, L., Secrest, P., Zhao, J., Varki, N., Lindheim, S., & Gagneux, P. (2012). Sialidases on mammalian sperm mediate deciduous sialylation during capacitation. Journal of Biological Chemistry, 287(45), 38073-38079. https://doi.org/10.1074/jbc.M112.380584