Short-term treatment with a lipid-lowering agent: Diethylaminoethyldextran (Dexide). Excretion of bile acids, neutral sterols and faecal fats

M. Arca, S. Ciocca, S. Fazio

    Research output: Contribution to journalArticle

    1 Scopus citations

    Abstract

    The faecal excretion of bile acids, neutral sterols and total fats were measured in 13 hyperlipaemic outpatients (7 type II A or B, and 6 type IV), and in 1 normal subject during 15- or 30-days' treatment with 3.0 gm daily of diethylaminoethyldextran (Dexide). After 15 days, the faecal excretion of neutral sterols, bile acids and total fats showed a significant increase (59, 87 and 170% respectively). In eight patients, whose drug treatment lasted 30 days, a further although non-significant increase was recorded as compared to 15-day values. This effect appeared to be more pronounced in type IV patients. In type II patients the faecal fat excretion showed a gradual increase after 15 and 30 days respectively, whereas in type IV patients the peak value was reached by the end of the first 15-day period and remained unchanged thereafter. In both types of hyperlipoproteinaemia the percentage increase of total fatty acid excretion appeared to be higher than that of neutral and acid sterols.

    Original languageEnglish (US)
    Pages (from-to)198-206
    Number of pages9
    JournalClinical Trials Journal
    Volume19
    Issue number4
    StatePublished - Jan 1 1982

    ASJC Scopus subject areas

    • Pharmacology (medical)

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