Short-term treatment with a lipid-lowering agent

Diethylaminoethyldextran (Dexide). Excretion of bile acids, neutral sterols and faecal fats

M. Arca, S. Ciocca, Sergio Fazio

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The faecal excretion of bile acids, neutral sterols and total fats were measured in 13 hyperlipaemic outpatients (7 type II A or B, and 6 type IV), and in 1 normal subject during 15- or 30-days' treatment with 3.0 gm daily of diethylaminoethyldextran (Dexide). After 15 days, the faecal excretion of neutral sterols, bile acids and total fats showed a significant increase (59, 87 and 170% respectively). In eight patients, whose drug treatment lasted 30 days, a further although non-significant increase was recorded as compared to 15-day values. This effect appeared to be more pronounced in type IV patients. In type II patients the faecal fat excretion showed a gradual increase after 15 and 30 days respectively, whereas in type IV patients the peak value was reached by the end of the first 15-day period and remained unchanged thereafter. In both types of hyperlipoproteinaemia the percentage increase of total fatty acid excretion appeared to be higher than that of neutral and acid sterols.

Original languageEnglish (US)
Pages (from-to)198-206
Number of pages9
JournalClinical Trials Journal
Volume19
Issue number4
StatePublished - 1982
Externally publishedYes

Fingerprint

DEAE-Dextran
Sterols
Bile Acids and Salts
Fats
Lipids
Hyperlipoproteinemias
Therapeutics
Outpatients
Fatty Acids
Acids
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

@article{41df4bcc1cce4140a1a047dc6a432d82,
title = "Short-term treatment with a lipid-lowering agent: Diethylaminoethyldextran (Dexide). Excretion of bile acids, neutral sterols and faecal fats",
abstract = "The faecal excretion of bile acids, neutral sterols and total fats were measured in 13 hyperlipaemic outpatients (7 type II A or B, and 6 type IV), and in 1 normal subject during 15- or 30-days' treatment with 3.0 gm daily of diethylaminoethyldextran (Dexide). After 15 days, the faecal excretion of neutral sterols, bile acids and total fats showed a significant increase (59, 87 and 170{\%} respectively). In eight patients, whose drug treatment lasted 30 days, a further although non-significant increase was recorded as compared to 15-day values. This effect appeared to be more pronounced in type IV patients. In type II patients the faecal fat excretion showed a gradual increase after 15 and 30 days respectively, whereas in type IV patients the peak value was reached by the end of the first 15-day period and remained unchanged thereafter. In both types of hyperlipoproteinaemia the percentage increase of total fatty acid excretion appeared to be higher than that of neutral and acid sterols.",
author = "M. Arca and S. Ciocca and Sergio Fazio",
year = "1982",
language = "English (US)",
volume = "19",
pages = "198--206",
journal = "Clinical Trials Journal",
issn = "0009-9325",
publisher = "Elsevier BV",
number = "4",

}

TY - JOUR

T1 - Short-term treatment with a lipid-lowering agent

T2 - Diethylaminoethyldextran (Dexide). Excretion of bile acids, neutral sterols and faecal fats

AU - Arca, M.

AU - Ciocca, S.

AU - Fazio, Sergio

PY - 1982

Y1 - 1982

N2 - The faecal excretion of bile acids, neutral sterols and total fats were measured in 13 hyperlipaemic outpatients (7 type II A or B, and 6 type IV), and in 1 normal subject during 15- or 30-days' treatment with 3.0 gm daily of diethylaminoethyldextran (Dexide). After 15 days, the faecal excretion of neutral sterols, bile acids and total fats showed a significant increase (59, 87 and 170% respectively). In eight patients, whose drug treatment lasted 30 days, a further although non-significant increase was recorded as compared to 15-day values. This effect appeared to be more pronounced in type IV patients. In type II patients the faecal fat excretion showed a gradual increase after 15 and 30 days respectively, whereas in type IV patients the peak value was reached by the end of the first 15-day period and remained unchanged thereafter. In both types of hyperlipoproteinaemia the percentage increase of total fatty acid excretion appeared to be higher than that of neutral and acid sterols.

AB - The faecal excretion of bile acids, neutral sterols and total fats were measured in 13 hyperlipaemic outpatients (7 type II A or B, and 6 type IV), and in 1 normal subject during 15- or 30-days' treatment with 3.0 gm daily of diethylaminoethyldextran (Dexide). After 15 days, the faecal excretion of neutral sterols, bile acids and total fats showed a significant increase (59, 87 and 170% respectively). In eight patients, whose drug treatment lasted 30 days, a further although non-significant increase was recorded as compared to 15-day values. This effect appeared to be more pronounced in type IV patients. In type II patients the faecal fat excretion showed a gradual increase after 15 and 30 days respectively, whereas in type IV patients the peak value was reached by the end of the first 15-day period and remained unchanged thereafter. In both types of hyperlipoproteinaemia the percentage increase of total fatty acid excretion appeared to be higher than that of neutral and acid sterols.

UR - http://www.scopus.com/inward/record.url?scp=0019978394&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019978394&partnerID=8YFLogxK

M3 - Article

VL - 19

SP - 198

EP - 206

JO - Clinical Trials Journal

JF - Clinical Trials Journal

SN - 0009-9325

IS - 4

ER -