Abstract
We previously described a biphasic dose-response curve for ethinyl estradiol on short term growth in patients with Turner's syndrome. To investigate whether there is a similar phenomenon in boys, we measured the 3-week ulnar growth velocity (TUG) after administration of different doses of estradiol to five prepubertal or early pubertal boys. Basal TUG was determined initially. Subsequently, the boys received a 4-day iv infusion of estradiol at each of three doses (4, 20, and 90 μg/day) given double blind in a randomized sequence. TUG was determined before and after each infusion and was allowed to return to baseline before giving the second and third infusions. Mean TUG increased from 0.45 ± 0.11 (± SEM) to 1.38 ± 0.51 mm/3 weeks after the 4 μg/day infusion (P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 896-898 |
| Number of pages | 3 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 61 |
| Issue number | 5 |
| State | Published - 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Endocrinology, Diabetes and Metabolism
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Short term, low dose estradiol accelerates ulnar growth in boys. / Caruso-Nicoletti, M.; Cassorla, F.; Skerda, M.; Ross, J. L.; Loriaux, Donald (Lynn); Cutler, G. B.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 61, No. 5, 1985, p. 896-898.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Short term, low dose estradiol accelerates ulnar growth in boys
AU - Caruso-Nicoletti, M.
AU - Cassorla, F.
AU - Skerda, M.
AU - Ross, J. L.
AU - Loriaux, Donald (Lynn)
AU - Cutler, G. B.
PY - 1985
Y1 - 1985
N2 - We previously described a biphasic dose-response curve for ethinyl estradiol on short term growth in patients with Turner's syndrome. To investigate whether there is a similar phenomenon in boys, we measured the 3-week ulnar growth velocity (TUG) after administration of different doses of estradiol to five prepubertal or early pubertal boys. Basal TUG was determined initially. Subsequently, the boys received a 4-day iv infusion of estradiol at each of three doses (4, 20, and 90 μg/day) given double blind in a randomized sequence. TUG was determined before and after each infusion and was allowed to return to baseline before giving the second and third infusions. Mean TUG increased from 0.45 ± 0.11 (± SEM) to 1.38 ± 0.51 mm/3 weeks after the 4 μg/day infusion (P
AB - We previously described a biphasic dose-response curve for ethinyl estradiol on short term growth in patients with Turner's syndrome. To investigate whether there is a similar phenomenon in boys, we measured the 3-week ulnar growth velocity (TUG) after administration of different doses of estradiol to five prepubertal or early pubertal boys. Basal TUG was determined initially. Subsequently, the boys received a 4-day iv infusion of estradiol at each of three doses (4, 20, and 90 μg/day) given double blind in a randomized sequence. TUG was determined before and after each infusion and was allowed to return to baseline before giving the second and third infusions. Mean TUG increased from 0.45 ± 0.11 (± SEM) to 1.38 ± 0.51 mm/3 weeks after the 4 μg/day infusion (P
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UR - http://www.scopus.com/inward/citedby.url?scp=0022361728&partnerID=8YFLogxK
M3 - Article
C2 - 4044777
AN - SCOPUS:0022361728
VL - 61
SP - 896
EP - 898
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 5
ER -