Short term, low dose estradiol accelerates ulnar growth in boys

M. Caruso-Nicoletti, F. Cassorla, M. Skerda, J. L. Ross, Donald (Lynn) Loriaux, G. B. Cutler

Research output: Contribution to journalArticle

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Abstract

We previously described a biphasic dose-response curve for ethinyl estradiol on short term growth in patients with Turner's syndrome. To investigate whether there is a similar phenomenon in boys, we measured the 3-week ulnar growth velocity (TUG) after administration of different doses of estradiol to five prepubertal or early pubertal boys. Basal TUG was determined initially. Subsequently, the boys received a 4-day iv infusion of estradiol at each of three doses (4, 20, and 90 μg/day) given double blind in a randomized sequence. TUG was determined before and after each infusion and was allowed to return to baseline before giving the second and third infusions. Mean TUG increased from 0.45 ± 0.11 (± SEM) to 1.38 ± 0.51 mm/3 weeks after the 4 μg/day infusion (P

Original languageEnglish (US)
Pages (from-to)896-898
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume61
Issue number5
StatePublished - 1985
Externally publishedYes

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Estradiol
Ethinyl Estradiol
Growth
Turner Syndrome
Scanning electron microscopy

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Caruso-Nicoletti, M., Cassorla, F., Skerda, M., Ross, J. L., Loriaux, D. L., & Cutler, G. B. (1985). Short term, low dose estradiol accelerates ulnar growth in boys. Journal of Clinical Endocrinology and Metabolism, 61(5), 896-898.

Short term, low dose estradiol accelerates ulnar growth in boys. / Caruso-Nicoletti, M.; Cassorla, F.; Skerda, M.; Ross, J. L.; Loriaux, Donald (Lynn); Cutler, G. B.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 61, No. 5, 1985, p. 896-898.

Research output: Contribution to journalArticle

Caruso-Nicoletti, M, Cassorla, F, Skerda, M, Ross, JL, Loriaux, DL & Cutler, GB 1985, 'Short term, low dose estradiol accelerates ulnar growth in boys', Journal of Clinical Endocrinology and Metabolism, vol. 61, no. 5, pp. 896-898.
Caruso-Nicoletti M, Cassorla F, Skerda M, Ross JL, Loriaux DL, Cutler GB. Short term, low dose estradiol accelerates ulnar growth in boys. Journal of Clinical Endocrinology and Metabolism. 1985;61(5):896-898.
Caruso-Nicoletti, M. ; Cassorla, F. ; Skerda, M. ; Ross, J. L. ; Loriaux, Donald (Lynn) ; Cutler, G. B. / Short term, low dose estradiol accelerates ulnar growth in boys. In: Journal of Clinical Endocrinology and Metabolism. 1985 ; Vol. 61, No. 5. pp. 896-898.
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