Short-term folic acid supplementation induces variable and paradoxical changes in plasma homocyst(e)ine concentrations

M. René Malinow, Paul Duell, Michelle A. Williams, Warren D. Kruger, Alison A. Evans, Peter H. Anderson, Peter C. Block, David Hess, Barbara M. Upson, Eric E. Graf, Andrea Irvin-Jones, Liqun Wang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Folic acid is presently the mainstay of treatment for most subjects with elevated plasma homocyst(e)ine concentrations [Plasma or serum homocyst(e)ine, or total homocysteine, refers to the sum of the sulfhydryl amino acid homocysteine and the homocysteinyl moieties of the disulfides homocystine and homocystein-cysteine, whether free or bound to plasma proteins.] Changes in homocyst(e)ine in response to folic acid supplementation are characterized by considerable interindividual variation. The purpose of this study was to identify factors that contribute to heterogeneity in short-term responses to folic acid supplementation. The effects of folic acid supplementation (1 or 2 mg per day) for 3 wk on plasma homocyst(e)ine concentrations were assessed in 304 men and women. Overall, folic acid supplementation increased mean plasma folate 31.5 ± 98.0 μmol/L and decreased mean plasma homocyst(e)ine concentrations 1.2 ± 2.4 μmol/L. There was evidence of substantial interindividual variation in the homocyst(e)ine response from -18.5 to +7.1 μmol/L, including an increase in homocyst(e)ine in 20% of subjects (mean increase 1.5 ± 1.4 μmol/L). Basal homocyst(e)ine, age, male gender, cigarette smoking, use of multivitamins, methylene tetrahydrofolate reductase, and cystathionine β-synthase polymorphisms accounted for 47.6% of the interindividual variability in the change in homocyst(e)ine after folic acid supplementation, but about 50% of variability in response to folic acid was not explained by the variables we studied.

Original languageEnglish (US)
JournalLipids
Volume36
Issue numberSUPPL.
StatePublished - 2001

Fingerprint

Folic Acid
folic acid
Plasmas
homocysteine
Homocysteine
Homocystine
Cystathionine
methylenetetrahydrofolate reductase
cystathionine
Methylenetetrahydrofolate Reductase (NADPH2)
smoking (habit)
Polymorphism
sulfides
Tobacco Products
Disulfides
blood proteins
Cysteine
cysteine
Blood Proteins
Smoking

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Food Science
  • Biochemistry

Cite this

Malinow, M. R., Duell, P., Williams, M. A., Kruger, W. D., Evans, A. A., Anderson, P. H., ... Wang, L. (2001). Short-term folic acid supplementation induces variable and paradoxical changes in plasma homocyst(e)ine concentrations. Lipids, 36(SUPPL.).

Short-term folic acid supplementation induces variable and paradoxical changes in plasma homocyst(e)ine concentrations. / Malinow, M. René; Duell, Paul; Williams, Michelle A.; Kruger, Warren D.; Evans, Alison A.; Anderson, Peter H.; Block, Peter C.; Hess, David; Upson, Barbara M.; Graf, Eric E.; Irvin-Jones, Andrea; Wang, Liqun.

In: Lipids, Vol. 36, No. SUPPL., 2001.

Research output: Contribution to journalArticle

Malinow, MR, Duell, P, Williams, MA, Kruger, WD, Evans, AA, Anderson, PH, Block, PC, Hess, D, Upson, BM, Graf, EE, Irvin-Jones, A & Wang, L 2001, 'Short-term folic acid supplementation induces variable and paradoxical changes in plasma homocyst(e)ine concentrations', Lipids, vol. 36, no. SUPPL..
Malinow, M. René ; Duell, Paul ; Williams, Michelle A. ; Kruger, Warren D. ; Evans, Alison A. ; Anderson, Peter H. ; Block, Peter C. ; Hess, David ; Upson, Barbara M. ; Graf, Eric E. ; Irvin-Jones, Andrea ; Wang, Liqun. / Short-term folic acid supplementation induces variable and paradoxical changes in plasma homocyst(e)ine concentrations. In: Lipids. 2001 ; Vol. 36, No. SUPPL.
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AU - Malinow, M. René

AU - Duell, Paul

AU - Williams, Michelle A.

AU - Kruger, Warren D.

AU - Evans, Alison A.

AU - Anderson, Peter H.

AU - Block, Peter C.

AU - Hess, David

AU - Upson, Barbara M.

AU - Graf, Eric E.

AU - Irvin-Jones, Andrea

AU - Wang, Liqun

PY - 2001

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