TY - JOUR
T1 - Short communication
T2 - Oxidative stress in HIV-infected individuals: A cross-sectional study
AU - Wanchu, Ajay
AU - Rana, S. V.
AU - Pallikkuth, Suresh
AU - Sachdeva, Ravinder Kaur
PY - 2009/12/1
Y1 - 2009/12/1
N2 - HIV infection increases the oxidative stress process, and antiretroviral combination therapy increases protein oxidation and preexistent oxidative stress. The latter induces production of reactive oxygen species. Lipid peroxidation (LPO) is a means of determining oxidative stress. There is also a deficiency of glutathione in HIV infection. Persistent oxidative load leads to an accelerated rate of consumption of glutathione (GSH). This study measured LPO and GSH levels in plasma of HIV-infected individuals with or without therapy and compared these with healthy controls. One hundred HIV-infected individuals and 30 healthy controls were included in the study. LPO and GSH levels were measured in plasma according to previously described methods. The mean level of LPO in HIV-infected individuals was 0.7±0.1μmol/ml (range, 0.5-0.9μmol/ml), whereas the mean LPO level in controls was 0.3±0.1μmol/ml (range, 0.2-0.4μmol/ml). The mean LPO levels were significantly higher in HIV-infected individuals as compared to healthy controls (p value<0.0001). The mean GSH level in HIV-infected individuals was 0.06±0.01μmol/ml (range, 0.03-0.08). The mean GSH level in healthy controls was 0.09±0.01μmol/ml (range, 0.05-0.1). The mean glutathione level in HIV-infected individuals was significantly lower in compared to healthy controls (p value<0.0001). There was a significant positive correlation between absolute CD4 cells and GSH levels (ρ=0.182, p=0.045). There is increased oxidative stress in HIV-infected patients. Whether supplementation with antioxidants will reduce this oxidative stress is still unknown.
AB - HIV infection increases the oxidative stress process, and antiretroviral combination therapy increases protein oxidation and preexistent oxidative stress. The latter induces production of reactive oxygen species. Lipid peroxidation (LPO) is a means of determining oxidative stress. There is also a deficiency of glutathione in HIV infection. Persistent oxidative load leads to an accelerated rate of consumption of glutathione (GSH). This study measured LPO and GSH levels in plasma of HIV-infected individuals with or without therapy and compared these with healthy controls. One hundred HIV-infected individuals and 30 healthy controls were included in the study. LPO and GSH levels were measured in plasma according to previously described methods. The mean level of LPO in HIV-infected individuals was 0.7±0.1μmol/ml (range, 0.5-0.9μmol/ml), whereas the mean LPO level in controls was 0.3±0.1μmol/ml (range, 0.2-0.4μmol/ml). The mean LPO levels were significantly higher in HIV-infected individuals as compared to healthy controls (p value<0.0001). The mean GSH level in HIV-infected individuals was 0.06±0.01μmol/ml (range, 0.03-0.08). The mean GSH level in healthy controls was 0.09±0.01μmol/ml (range, 0.05-0.1). The mean glutathione level in HIV-infected individuals was significantly lower in compared to healthy controls (p value<0.0001). There was a significant positive correlation between absolute CD4 cells and GSH levels (ρ=0.182, p=0.045). There is increased oxidative stress in HIV-infected patients. Whether supplementation with antioxidants will reduce this oxidative stress is still unknown.
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U2 - 10.1089/aid.2009.0062
DO - 10.1089/aid.2009.0062
M3 - Article
C2 - 20001519
AN - SCOPUS:73149120058
SN - 0889-2229
VL - 25
SP - 1307
EP - 1311
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
IS - 12
ER -