Short communication: Oxidative stress in HIV-infected individuals: A cross-sectional study

Ajay Wanchu, S. V. Rana, Suresh Pallikkuth, Ravinder Kaur Sachdeva

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

HIV infection increases the oxidative stress process, and antiretroviral combination therapy increases protein oxidation and preexistent oxidative stress. The latter induces production of reactive oxygen species. Lipid peroxidation (LPO) is a means of determining oxidative stress. There is also a deficiency of glutathione in HIV infection. Persistent oxidative load leads to an accelerated rate of consumption of glutathione (GSH). This study measured LPO and GSH levels in plasma of HIV-infected individuals with or without therapy and compared these with healthy controls. One hundred HIV-infected individuals and 30 healthy controls were included in the study. LPO and GSH levels were measured in plasma according to previously described methods. The mean level of LPO in HIV-infected individuals was 0.7±0.1μmol/ml (range, 0.5-0.9μmol/ml), whereas the mean LPO level in controls was 0.3±0.1μmol/ml (range, 0.2-0.4μmol/ml). The mean LPO levels were significantly higher in HIV-infected individuals as compared to healthy controls (p value

Original languageEnglish (US)
Pages (from-to)1307-1311
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume25
Issue number12
DOIs
StatePublished - Dec 1 2009
Externally publishedYes

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Lipid Peroxidation
Oxidative Stress
Cross-Sectional Studies
HIV
HIV Infections
Glutathione
Reactive Oxygen Species
Therapeutics
Proteins

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Short communication : Oxidative stress in HIV-infected individuals: A cross-sectional study. / Wanchu, Ajay; Rana, S. V.; Pallikkuth, Suresh; Sachdeva, Ravinder Kaur.

In: AIDS Research and Human Retroviruses, Vol. 25, No. 12, 01.12.2009, p. 1307-1311.

Research output: Contribution to journalArticle

Wanchu, Ajay ; Rana, S. V. ; Pallikkuth, Suresh ; Sachdeva, Ravinder Kaur. / Short communication : Oxidative stress in HIV-infected individuals: A cross-sectional study. In: AIDS Research and Human Retroviruses. 2009 ; Vol. 25, No. 12. pp. 1307-1311.
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