Short- and long, duration responses to levodopa during the first year of levodopa therapy

John Nutt, Julie Carter, Laura Van Houten, William Woodward

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

We examined the response to 2-hour levodopa infusions in 18 Parkinson's disease subjects before starting long-term levodopa treatment and after 6 and 12 months of treatment using tapping speed as an index of bradykinesia. The long-duration response (LDR), measured as the increase in baseline (overnight without levodopa) tapping speed, increased by 29 ± 18 at 6 months and by 35 ± 24 at 12 months. The magnitude of the short-duration response (SDR) to a 2-hour levodopa infusion after an overnight levodopa withdrawal did not differ at 6 and 12 months (16 ± 8 and 20 ± 13 taps/min) from that before long-term levodopa (21 ± taps/min). However, when levodopa was withheld for 3 days, it was evident that the SDR magnitude was increasing in magnitude (19, 23, and 31 taps/min at 0, 6, and 12 months). Duration of SDR did not change. A diurnal motor pattern with faster tapping speeds in the morning and slower in the evening was apparent on the days no levodopa was administered. These observations indicate (1) the LDR is responsible for much of the sustained response to levodopa during the first year of treatment, (2) the SDR magnitude increases but is obscured by the LDR, and (3) a diurnal pattern of motor function is present that may be partially responsible for the poorer motor function in the afternoons and evenings.

Original languageEnglish (US)
Pages (from-to)349-355
Number of pages7
JournalAnnals of Neurology
Volume42
Issue number3
DOIs
StatePublished - Sep 1997

Fingerprint

Levodopa
Therapeutics
Hypokinesia
Parkinson Disease

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Short- and long, duration responses to levodopa during the first year of levodopa therapy. / Nutt, John; Carter, Julie; Van Houten, Laura; Woodward, William.

In: Annals of Neurology, Vol. 42, No. 3, 09.1997, p. 349-355.

Research output: Contribution to journalArticle

@article{9984c6fe53e241829823890f2998f315,
title = "Short- and long, duration responses to levodopa during the first year of levodopa therapy",
abstract = "We examined the response to 2-hour levodopa infusions in 18 Parkinson's disease subjects before starting long-term levodopa treatment and after 6 and 12 months of treatment using tapping speed as an index of bradykinesia. The long-duration response (LDR), measured as the increase in baseline (overnight without levodopa) tapping speed, increased by 29 ± 18 at 6 months and by 35 ± 24 at 12 months. The magnitude of the short-duration response (SDR) to a 2-hour levodopa infusion after an overnight levodopa withdrawal did not differ at 6 and 12 months (16 ± 8 and 20 ± 13 taps/min) from that before long-term levodopa (21 ± taps/min). However, when levodopa was withheld for 3 days, it was evident that the SDR magnitude was increasing in magnitude (19, 23, and 31 taps/min at 0, 6, and 12 months). Duration of SDR did not change. A diurnal motor pattern with faster tapping speeds in the morning and slower in the evening was apparent on the days no levodopa was administered. These observations indicate (1) the LDR is responsible for much of the sustained response to levodopa during the first year of treatment, (2) the SDR magnitude increases but is obscured by the LDR, and (3) a diurnal pattern of motor function is present that may be partially responsible for the poorer motor function in the afternoons and evenings.",
author = "John Nutt and Julie Carter and {Van Houten}, Laura and William Woodward",
year = "1997",
month = "9",
doi = "10.1002/ana.410420311",
language = "English (US)",
volume = "42",
pages = "349--355",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Short- and long, duration responses to levodopa during the first year of levodopa therapy

AU - Nutt, John

AU - Carter, Julie

AU - Van Houten, Laura

AU - Woodward, William

PY - 1997/9

Y1 - 1997/9

N2 - We examined the response to 2-hour levodopa infusions in 18 Parkinson's disease subjects before starting long-term levodopa treatment and after 6 and 12 months of treatment using tapping speed as an index of bradykinesia. The long-duration response (LDR), measured as the increase in baseline (overnight without levodopa) tapping speed, increased by 29 ± 18 at 6 months and by 35 ± 24 at 12 months. The magnitude of the short-duration response (SDR) to a 2-hour levodopa infusion after an overnight levodopa withdrawal did not differ at 6 and 12 months (16 ± 8 and 20 ± 13 taps/min) from that before long-term levodopa (21 ± taps/min). However, when levodopa was withheld for 3 days, it was evident that the SDR magnitude was increasing in magnitude (19, 23, and 31 taps/min at 0, 6, and 12 months). Duration of SDR did not change. A diurnal motor pattern with faster tapping speeds in the morning and slower in the evening was apparent on the days no levodopa was administered. These observations indicate (1) the LDR is responsible for much of the sustained response to levodopa during the first year of treatment, (2) the SDR magnitude increases but is obscured by the LDR, and (3) a diurnal pattern of motor function is present that may be partially responsible for the poorer motor function in the afternoons and evenings.

AB - We examined the response to 2-hour levodopa infusions in 18 Parkinson's disease subjects before starting long-term levodopa treatment and after 6 and 12 months of treatment using tapping speed as an index of bradykinesia. The long-duration response (LDR), measured as the increase in baseline (overnight without levodopa) tapping speed, increased by 29 ± 18 at 6 months and by 35 ± 24 at 12 months. The magnitude of the short-duration response (SDR) to a 2-hour levodopa infusion after an overnight levodopa withdrawal did not differ at 6 and 12 months (16 ± 8 and 20 ± 13 taps/min) from that before long-term levodopa (21 ± taps/min). However, when levodopa was withheld for 3 days, it was evident that the SDR magnitude was increasing in magnitude (19, 23, and 31 taps/min at 0, 6, and 12 months). Duration of SDR did not change. A diurnal motor pattern with faster tapping speeds in the morning and slower in the evening was apparent on the days no levodopa was administered. These observations indicate (1) the LDR is responsible for much of the sustained response to levodopa during the first year of treatment, (2) the SDR magnitude increases but is obscured by the LDR, and (3) a diurnal pattern of motor function is present that may be partially responsible for the poorer motor function in the afternoons and evenings.

UR - http://www.scopus.com/inward/record.url?scp=0030799456&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030799456&partnerID=8YFLogxK

U2 - 10.1002/ana.410420311

DO - 10.1002/ana.410420311

M3 - Article

C2 - 9307256

AN - SCOPUS:0030799456

VL - 42

SP - 349

EP - 355

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 3

ER -